Effects of Poncirus trifoliata on type I hypersensitivity reaction

The American Journal of Chinese Medicine
Y M LeeH M Kim

Abstract

A study was carried out to examine the effect of an aqueous extract from immature fruit of Poncirus trifoliata L. (Rutaceae) (PTIFE) on the type I hypersensitivity reaction. Forty-eight hour PCA (passive cutaneous anaphylaxis) in rats was significantly inhibited by the oral administration of PTIFE (200 mg/kg). It also inhibited histamine release from rat peritoneal mast cells (RPMC) induced by mouse anti-dinitrophenyl (DNP)-IgE and dinitrophenyl-human serum albumin (DNP-HSA). These results suggest that PTIFE has anti-allergic action against the type I hypersensitivity reaction.

Citations

Sep 10, 2003·Journal of Ethnopharmacology·Seung-Heon HongHyung-Min Kim
Apr 1, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tae-Yong ShinSang-Hyun Kim
Sep 30, 2005·Journal of Ethnopharmacology·Hyun-Tai LeeChang-Koo Shim
Oct 30, 2008·Journal of Immunotoxicology·Shailaja G Mahajan, Anita A Mehta

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