Effects of positive end-expiratory pressure on oscillated flow rate during high-frequency chest compression

Chest
R J PerryR L Jones

Abstract

To investigate the effects of positive end-expiratory pressure (PEEP) on end-expiratory lung volume (EELV) and mean oscillated flow rate (VOSC) during high-frequency chest compression (HFCC) in normal subjects and patients with severe COPD. Comparative study. Pulmonary function and lung mechanics laboratory, University of Alberta Hospitals. Six normal subjects (five male; one female) and six patients with clinically stable COPD (five male; one female) with hypercapnia. A pneumatic vest system was operated at 10 Hz with a mean chest wall pressure of 16 cm H2O to provide the HFCC. A closed-circuit spirometer system permitted measurement of HFCC- and PEEP-induced changes in EELV that were expressed as per cent baseline functional residual capacity (FRC). An isothermic chamber connected near the mouthpiece permitted measurement of VOSC. For the normal subjects, HFCC caused a significant decrease in EELV to 82.0% of FRC (p < or = 0.01) and the addition of 4.8+/-0.5 cm H2O of PEEP during HFCC increased EELV to 97.5% FRC. In the COPD patients, HFCC decreased EELV to 92.3% of FRC (p < or = 0.01), and the addition of 3.7+/-1.0 cm H2O of PEEP increased EELV to 98.4% FRC. For the normal subjects, increasing EELV to near FRC caused VOSC du...Continue Reading

References

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Citations

May 30, 2012·Clinics in Chest Medicine·Lizzie J FludeDiana Bilton
Mar 13, 2012·Revue des maladies respiratoires·G ReychlerP Lebecque
Sep 5, 2014·The Clinical Respiratory Journal·Wei-Chang HuangChieh-Liang Wu
Dec 19, 2008·Respiratory Medicine·Angshu BhowmikIndranil Chakravorty
Nov 18, 2008·Biomedical Instrumentation & Technology·Tal ZuckerRichard L Jones

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