Effects of post-processing methods on chitosan-genipin hydrogel properties

Materials Science & Engineering. C, Materials for Biological Applications
Abitha M HeimbuckMary E Caldorera-Moore

Abstract

Biopolymer based hydrogel materials are attractive options for a variety of medical applications, including drug delivery and tissue regeneration because of their innate biomimetic material properties. While biopolymers are typically selected for a specific application based off of their chemical properties; the overall material structure of the resulting hydrogel ultimately relates to its ability to function for its intended application. In view of this, it is imperative that the impact of commonly used drying procedures on hydrogel physical properties is well understood. Herein, the effects of post-synthesis drying techniques: air-drying and lyophilization, on genipin crosslinked chitosan hydrogel physical structure were studied. Chitosan-genipin hydrogels synthesized out of either 15 kDa MW or 50-190 kDa MW chitosan were either air-dried (AD), flash-frozen (FF) and then lyophilized, or step-down frozen (SD) and then lyophilized. Environmental scanning electron microscopy (ESEM) was employed to evaluate the resulting hydrogels physical structure as a function of chitosan molecular weight and drying condition. ESEM images revealed the presence of larger microscale pores within the SD samples compared to FF samples, but both tr...Continue Reading

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Citations

Mar 4, 2020·Environmental Science and Pollution Research International·Hongxue DuMingyue Piao
Aug 11, 2020·Environmental Technology·Dongliang Hao, Yali Liang
May 1, 2019·Journal of Biomaterials Science. Polymer Edition·Haley H BarnettMary E Caldorera-Moore
Apr 18, 2021·International Journal of Biological Macromolecules·Yale Luck NunesJosé C S Dos Santos
Oct 9, 2019·International Journal of Biological Macromolecules·Danilo M Dos SantosDaniel S Correa
Apr 4, 2020·ACS Applied Materials & Interfaces·Qiang FuNa Na
Feb 19, 2020·Journal of Agricultural and Food Chemistry·Chenglong JiangJingbo Wu

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