Effects of postnatal stress on the development of type 1 diabetes in bank voles (Clethrionomys glareolus)

International Journal of Experimental Diabesity Research
T FreimanisMogens Bildsøe

Abstract

Wild bank voles (Clethrionomys glareolus) kept in the laboratory under barren housing conditions develop high incidences of type 1 diabetes mellitus due to beta cell-specific lysis in association with the appearance of GAD65, IA-2, and insulin autoantibodies. Wild-caught and immediately analyzed voles show no histological signs of diabetes, and the disease may therefore be induced by circumstances related to the housing of the animals in captivity. We tested the possibility that postnatal stress by either maternal separation or water immersion at different intervals would induce diabetes in adult bank voles. We found that low-frequent stress during the first 21 days of life increases, whereas high-frequent stress markedly reduces, the incidence of type 1 diabetes in adulthood. These results differentiate the role of early-experienced stress on subsequent type 1 diabetes development and emphasize that the bank vole may serve as a useful new animal model for the disease.

Citations

Aug 9, 2006·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Annika SamsioeBo Niklasson
Mar 6, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Bo NiklassonWilliam Klitz
Jan 8, 2013·General and Comparative Endocrinology·Aleksandra BartelikAlicja Józkowicz
Jan 22, 2011·Brain, Behavior, and Immunity·Adam K WalkerDeborah M Hodgson
Aug 10, 2016·Viral Immunology·Bo NiklassonWilliam Klitz
Jul 18, 2018·Pediatric Diabetes·Åshild Olsen Faresjö, Johnny Ludvigsson

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