PMID: 2501288Jun 1, 1989Paper

Effects of posture on the venodilatory response to nitroglycerin

Journal of Applied Physiology
J A GaschoR Zelis

Abstract

To determine the effects of posture on the venodilatory response to nitroglycerin (TNG), the change in forearm venous volume after inflation of an upper arm cuff to 30 mmHg above cuff zero (VV[30]) was measured during control conditions and after TNG (0.8 mg spray) in 18 healthy young volunteers in the supine position and the sitting position. VV[30] was 3.24 +/- 0.98 ml/100 ml arm in the supine position and 2.46 +/- 1.32 ml/100 ml arm in the sitting position. TNG increased VV[30] by 0.56 +/- 0.19 ml/100 ml arm in supine subjects, but by only 0.38 +/- 0.17 ml/100 ml arm in sitting subjects (P = 0.013). When limb volume was measured in the forearm and calf without using a cuff to produce venous congestion, the increase in limb volume with TNG was significantly greater in the sitting than in the supine position. Because the fall in both systolic and diastolic pressure and the rise in heart rate were significantly greater after TNG was administered in the sitting position, it is suggested that a greater reflex venoconstriction occurred in this posture, which antagonized the TNG-induced increase in venous distensibility. In the seated position, the effect of gravity more than compensated for the impaired venodilatory response to TN...Continue Reading

Citations

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·D A DuprezD L Clement
Apr 18, 1998·Clinical Physiology·G LeftheriotisJ L Saumet
Dec 9, 1992·Prehospital and Disaster Medicine·L L HermanE P Sloan
Jul 15, 2006·Journal of Applied Physiology·Colin N YoungWilliam B Farquhar
Jul 19, 2008·Journal of Applied Physiology·Erin P DelaneyWilliam B Farquhar
Mar 1, 2008·Journal of Applied Physiology·Colin N YoungDavid G Edwards
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·B I MazhbichS M Mazhbich

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