Effects of potassium concentration on firing patterns of low-calcium epileptiform activity in anesthetized rat hippocampus: inducing of persistent spike activity

Epilepsia
Zhouyan Feng, Dominique M Durand

Abstract

It has been shown that a low-calcium high-potassium solution can generate ictal-like epileptiform activity in vitro and in vivo. Moreover, during status epileptiform activity, the concentration of [K+]o increases, and the concentration of [Ca2+]o decreases in brain tissue. Therefore we tested the hypothesis that long-lasting persistent spike activity, similar to one of the patterns of status epilepticus, could be generated by a high-potassium, low-calcium solution in the hippocampus in vivo. Artificial cerebrospinal fluid was perfused over the surface of the exposed left dorsal hippocampus of anesthetized rats. A stimulating electrode and a recording probe were placed in the CA1 region. By elevating K+ concentration from 6 to 12 mM in the perfusate solution, the typical firing pattern of low-calcium ictal bursts was transformed into persistent spike activity in the CA1 region with synaptic transmission being suppressed by calcium chelator EGTA. The activity was characterized by double spikes repeated at a frequency approximately 4 Hz that could last for >1 h. The analysis of multiple unit activity showed that both elevating [K+]o and lowering [Ca2+]o decreased the inhibition period after the response of paired-pulse stimulation...Continue Reading

References

Nov 1, 1985·Journal of Neurophysiology·P A RuteckiD Johnston
Jan 1, 1988·Journal of Neurophysiology·S F Traynelis, R Dingledine
Sep 1, 1984·The Journal of Physiology·H L Haas, J G Jefferys
May 1, 1980·Canadian Journal of Physiology and Pharmacology·K KrnjevićR J Reiffenstein
Jul 1, 1993·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·D Durand
Jul 1, 1997·Epilepsy Research·C Hamani, L E Mello
Jun 30, 2000·Cell Biology International·F E DudekJ E Rash
Nov 14, 2000·Epilepsy Research·D J BorrisJ Kapur
Jan 11, 2002·Journal of Neurophysiology·Marom BiksonDominique M Durand
Oct 5, 2002·Journal of Neurophysiology·Shokrollah S JahromiPeter L Carlen
Mar 1, 2003·Biophysical Journal·Jianwei ShuaiDominique M Durand
Jun 13, 2003·Journal of Neurophysiology·Marom BiksonJohn G R Jefferys
Oct 10, 2003·Journal of Neurophysiology·Zhouyan Feng, Dominique M Durand

❮ Previous
Next ❯

Citations

Apr 7, 2007·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Wim van DrongelenMark Hereld
Jul 7, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dominique M DurandAlicia L Jensen
Jun 20, 2012·Epilepsia·Susan L CampbellHarald Sontheimer
May 9, 2012·Expert Systems with Applications·Y Tang, Dm Durand
Jan 9, 2015·Scientific Reports·Xing-Xing WuJianwei Shuai
Aug 4, 2006·Glia·Devin K Binder, Christian Steinhäuser
Mar 2, 2012·Glia·Devin K BinderOle Petter Ottersen
Apr 29, 2008·Biophysical Journal·Eun-Hyoung ParkDominique M Durand
Apr 29, 2016·Scientific Reports·L VisochekM Cohen-Armon
Mar 23, 2017·Biochemistry. Biokhimii︠a︡·L G Khaspekov, L E Frumkina
Jul 9, 2009·Journal of Zhejiang University. Science. B·Zhou-Yan FengJing Wang
Sep 13, 2008·Journal of Behavioral Medicine·Rebecca Stoia-CaraballoAmy M Lyons
Sep 26, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Xing-Xing Wu, J W Shuai

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

© 2022 Meta ULC. All rights reserved