Effects of potassium ions and sodium ions on membrane potential of epithelial cells in rat duodenum.

Biochimica Et Biophysica Acta
Y OkadaA Inouye

Abstract

1. Mucosal and serosal membrane potentials (Vm and Vs) of epithelial cells in rat duodenum were recorded together with the transmural potential differences (PDt). 2. The value of Vm in rat duodenum at 37 degrees C was about -53mV, being considerably greater than the values reported hitherto for the small intestine of various species. 3. When Cl- in the mucosal medium was partially replaced with SO42- at fixed mucosal Na+ and K+ concentrations ([Na+]m and [K+]m), the membrane potential was scarcely affected in the steady state several minutes after replacement, whereas marked changes in the potential were observed with varying [K+]m or [Na+]m. 4. As the mucosal K+ concentration increased at constant [Na+]m, Vm was gradually decreased (depolarization), together with the increase in PDt. Such a change in Vm caused by varying [K+]m obeys Nernst's equation in the range of [K+]m higher than about 60 mM. 5. At constant [K+]m, an increase in [Na+]m also caused the decrease of Vm for the lower [K+]m region, whereas Vm was not affected by such changes in [Na+]m in the range of [K+]m higher than approx. 60 mM. 6. The values of PNa/PK were obtained from the modified Goldman equation under an appropriate assumption. The ratio of the permeab...Continue Reading

References

Jan 5, 1972·Nature: New Biology·E Frömter, J Diamond

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Citations

Apr 15, 1976·Biophysics of Structure and Mechanism·Y Okada, A Inouye
Jan 1, 1997·Springer Seminars in Immunopathology·I C Davis, R L Owen
Jan 1, 1983·The Journal of Membrane Biology·E Stefani, M Cereijido
Jun 28, 1978·The Journal of Membrane Biology·S A LewisD C Eaton
Nov 1, 1982·Journal of Cellular Physiology·J FerrierI Smith
Jun 6, 2014·American Journal of Physiology. Cell Physiology·Kristian ThorsenPeter Ruoff
Jan 1, 1979·Membrane Biochemistry·Y Okada
Aug 4, 1977·The Journal of Membrane Biology·Y OkadaA Inouye
Jan 1, 1980·Membrane Biochemistry·W TsuchiyaA Inouye
May 1, 1989·The American Journal of Physiology·J F White, D Ellingsen
Sep 18, 1989·Biochimica Et Biophysica Acta·K B RajaT J Peters

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