Effects of potential agonist-replacement therapies for stimulant dependence on inhibitory control in cocaine abusers

The American Journal of Drug and Alcohol Abuse
Andrea R VansickelCraig R Rush

Abstract

Two experiments were conducted to determine whether methylphenidate or modafinil, two potential pharmacotherapies for stimulant dependence, would impair inhibitory behavior in cocaine users. Eleven cocaine abusers were administered methylphenidate (0, 15, 30, and 45 mg) or modafinil (0, 150, 300, and 450 mg) across four experimental sessions. A cued go-no-go task was used to measure response execution and inhibition. Subjective and cardiovascular measures were collected. Neither methylphenidate nor modafinil impaired inhibitory control, but produced prototypical subject-rated and cardiovascular effects. The results of these studies may have implications for the use of these drugs as agonist-replacement therapies for stimulant dependence.

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Citations

Oct 14, 2010·Experimental and Clinical Psychopharmacology·Jennifer L NewmanNancy K Mello
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pouya Tahsili-FahadanGary Aston-Jones
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chiang-Shan R LiRobert T Malison
Mar 18, 2011·British Journal of Pharmacology·Catharine A Winstanley
Apr 27, 2016·Drug and Alcohol Dependence·Stephanie Collins Reed, Suzette M Evans
Sep 28, 2016·The Cochrane Database of Systematic Reviews·Xavier CastellsDolors Capellà

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