Effects of PPAR-gamma ligands on vascular smooth muscle marker expression in hypertensive and normal arteries

American Journal of Physiology. Heart and Circulatory Physiology
Kevin B AtkinsFrank C Brosius

Abstract

Having previously demonstrated that glucose transporter-4 (GLUT4) expression was reduced in aortas and carotid arteries of deoxycorticosterone acetate (DOCA) salt-hypertensive rats, we hypothesized that troglitazone (TG), through activation of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), would stabilize GLUT4 expression and possibly preserve the differentiated phenotype in vascular smooth muscle cells. In DOCA salt-hypertensive rats treated with TG (100 mg/day), there was a significant (P < 0.001) decrease in systolic blood pressure (BP; 149.9 +/- 4.4 mmHg) compared with the untreated DOCA salt-hypertensive rats (202.2 +/- 10.34 mmHg). Separate trials with rosiglitazone (RS; 3 mg/day) demonstrated a significant (P < 0.001) decrease in BP (DOCA salt, 164.2 +/- 9.8 vs. DOCA-RS, 124.9 +/- 3.7 mmHg) comparable to that with TG. Expression of GLUT4, h-caldesmon, and smooth muscle myosin heavy chain SM2 was significantly decreased in aortas of DOCA salt-hypertensive rats and was reversed by TG to levels similar to those in aortas of sham-treated rats. TG (50 microM) induced GLUT4 and h-caldesmon expression in 24-h culture of explanted carotid arteries of DOCA salt-hypertensive rats, and the endogenous PPAR-gamma liga...Continue Reading

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Citations

Mar 6, 2009·American Journal of Physiology. Cell Physiology·Kevin B AtkinsFrank C Brosius
Feb 17, 2007·The Journal of Clinical Investigation·Sheng Zhong DuanRichard M Mortensen
May 13, 2010·Journal of Atherosclerosis and Thrombosis·Ryo HashimotoMasunori Matsuzaki
Feb 22, 2008·PPAR Research·Sheng Zhong DuanRichard M Mortensen
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yumei YeYochai Birnbaum
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kevin B AtkinsFrank C Brosius
Jan 29, 2014·Current Hypertension Reports·Akhilesh Rao, Ravi Nistala
Jun 13, 2006·Arquivos brasileiros de endocrinologia e metabologia·Ubiratan Fabres MachadoPatrícia M Seraphim
Nov 6, 2007·Physiological Measurement·Sheng Zhong DuanRichard M Mortensen

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