Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?

Expert Review of Cardiovascular Therapy
Brian N Finck

Abstract

Cardiovascular disease is exceptionally prevalent in patients with diabetes mellitus and is the most common cause of death. With the emerging pandemic of obesity and resulting metabolic abnormalities, the occurrence of cardiovascular disease is almost nearly certain to increase at a remarkable rate in the near future. Currently, several ligands for the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are prescribed as lipid-lowering and insulin-sensitizing drugs. The PPARs are ligand-activated transcription factors that influence the expression of the entire program of fatty acid utilization enzymes. It is believed that these compounds remedy glucose homeostasis and cardiovascular disease by lowering circulating lipid levels, improving the profile of secreted adipokines, as well as via their anti-inflammatory properties. Conversely, overexpression of the PPARalpha isoform in the muscle or heart of mice drives diminished glucose transporter gene expression and glucose uptake into those insulin target tissues. Although the effects of overexpressing PPARalpha in a specific tissue obviously differ from activating PPARalpha in a systemic manner, studies such as this may influence the development of the n...Continue Reading

References

Jun 8, 1999·The Journal of Clinical Investigation·S KerstenW Wahli
Nov 10, 2000·Biochemical and Biophysical Research Communications·W S CookJ K Reddy
Nov 23, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G ChinettiB Staels
Feb 24, 2001·Annals of Internal Medicine·A A ParulkarV A Fonseca
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L F MichaelB M Spiegelman
Apr 18, 2001·The Journal of Clinical Investigation·K TordjmanC F Semenkovich
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·W R OliverT M Willson
May 26, 2001·The Journal of Endocrinology·P DeleriveB Staels
Aug 25, 2001·Biochemical and Biophysical Research Communications·G B MooreJ C Clapham
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yaacov BarakRonald M Evans
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robyn CunardCarolyn J Kelly
Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Edward O OjukaJohn O Holloszy
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Ellen AasumTerje S Larsen
Sep 17, 2002·The American Journal of Cardiology·Kitt F Petersen, Gerald I Shulman
Oct 16, 2002·The Journal of Biological Chemistry·Hélène DuezBart Staels
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Haihong ZongGerald I Shulman
Jan 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ajay ChawlaRonald M Evans
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brian N FinckDaniel P Kelly
Jun 5, 2003·Biochimica Et Biophysica Acta·Jeffrey M PetersFrank J Gonzalez
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Serge LuquetPaul A Grimaldi
Nov 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andrew N CarleyDavid L Severson

❮ Previous
Next ❯

Citations

Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maleah Grover-McKay
Jun 18, 2009·American Journal of Physiology. Endocrinology and Metabolism·Louis Hue, Heinrich Taegtmeyer
Aug 14, 2010·PPAR Research·Yves LecarpentierJean-Louis Hébert
Apr 6, 2007·The British Journal of Nutrition·Mary C Sugden
Aug 25, 2012·Nursing Education Perspectives·Patricia A Sharpnack, Elizabeth A Madigan
Jan 6, 2021·Cardiovascular Diabetology·Lin WangZhengyuan Xia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

© 2021 Meta ULC. All rights reserved