Effects of pravastatin and bezafibrate on biliary lipid excretion and hepatic expression of Abcg5 and Abcg8 in the rat

Journal of Gastroenterology and Hepatology
Toshinori Kamisako, Hiroshi Ogawa

Abstract

Multidrug resistance associated gene product 2 (Mdr2) is believed to have a significant role in biliary cholesterol and phospholipid secretions. Both pravastatin and bezafibrate resulted in Mdr2 induction, but increased cholesterol secretion was observed only in pravastatin treatment. To explore the mechanism, the hepatic expression of genes that are responsible for the metabolism of the lipids was studied. Rats were divided into three experimental groups: (i) the control group; (ii) the bezafibrate group, which was fed a diet containing 0.45% bezafibrate for 5 days; and (iii) the pravastatin group, which was fed a diet containing 0.1% pravastatin for 5 days. Serum, hepatic and biliary lipids were measured by colorimetric assays and hepatic mRNA related to lipid metabolism was studied by reverse transcription-polymerase chain reaction (RT-PCR). In the bezafibrate group biliary phospholipid secretion was increased although cholesterol secretion was not increased. In the pravastatin group, biliary cholesterol and phospholipid secretions were significantly increased. The biliary cholesterol/phospholipid ratio was decreased in the bezafibrate group, but the ratio did not change in the pravastatin group. Hepatic Mdr2, Abcg5 and Abcg...Continue Reading

References

Dec 1, 1984·The Journal of Clinical Investigation·F NerviR Del Pozo
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Jul 23, 1997·JAMA : the Journal of the American Medical Association·P R HebertC H Hennekens
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CarrellaP A Weinhold
Sep 10, 2003·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshinori Kamisako, Hiroshi Ogawa

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Citations

Apr 29, 2010·Current Atherosclerosis Reports·Amit V Khera, Daniel J Rader
Apr 20, 2011·Journal of Gastroenterology and Hepatology·Gabriela KolouchovaStanislav Micuda
Dec 3, 2010·Journal of Lipid Research·André J TremblayPatrick Couture
Jul 17, 2015·Cancer Cell International·Khalid O AlfaroukCyril Rauch

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