PMID: 6168850Sep 1, 1981Paper

Effects of prazosin and phenoxybenzamine on alpha- and beta-receptor-mediated responses in intestinal resistance and capacitance vessels

Journal of Cardiovascular Pharmacology
P PatelC V Greenway

Abstract

Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance in the acutely denervated hindlimb bed but caused a slowly developing vasoconstriction in the acutely denervated intestinal bed. The vasoconstrictor responses to sympathetic nerve stimulation were reduced to a similar extent in both vascular beds. Since maximal doses of prazosin produce only partial block of the alpha-receptor responses, there may be more than one type of postsynaptic alpha-receptor, and it is suggested that the postsynaptic receptors are of both alpha 1- and alpha 2-types. In the intestinal bed, prazosin produced similar reductions in both resistance and capacitance responses to sympathetic nerve stimulation. In isolated guinea pig aorta and portal vein, prazosin blocked the responses to noradrenaline competitively, and the pA3 values for the aorta and portal vein were similar. Thus, no selectivity for resistance vessels compared to capacitance vessels could be demonstrated in the intestine, and t...Continue Reading

Citations

Dec 1, 1995·Digestive Diseases and Sciences·S Lange, D S Delbro
Sep 3, 1984·European Journal of Pharmacology·G R Bolt, P R Saxena
Jan 1, 1997·Pharmacology & Therapeutics·S M KhedunB Maharaj
Dec 1, 1996·The Journal of Pharmacy and Pharmacology·J J FerraraL M Flint
Apr 28, 2001·Journal of Pharmacological and Toxicological Methods·C C Pang
Jan 24, 2004·Anesthesiology·Simon Gelman, Phillip S Mushlin
Jan 20, 2017·Journal of the American Heart Association·Julian M StewartWouter Wieling
Dec 1, 1984·Journal of Autonomic Pharmacology·R YamamotoK Takasaki
Sep 1, 1986·Journal of Autonomic Pharmacology·D C Eikenburg, M F Lokhandwala

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