Effects of pre or posttraining dorsal hippocampus D-AP5 injection on fear conditioning to tone, background, and foreground context

Hippocampus
Eduardo Ekman Schenberg, Maria Gabriela Menezes Oliveira

Abstract

NMDA receptor antagonist D-AP5 was injected into the dorsal hippocampus of Wistar rats before or immediately after the training session in fear conditioning. Training was conducted both with signaled (background context) or unsignaled (foreground context) footshocks. Contextual fear conditioning was assessed 24 h later and tone fear conditioning 48 h after training (only in the signaled footshock condition). Pretraining injections impaired conditioned fear to contextual features, both in background and foreground configurations, whereas tone fear conditioning was left intact. Posttraining injections were ineffective in all cases. We conclude that dorsal hippocampal NMDA receptors are required for contextual fear acquisition independently of context saliency and that they are not required to early consolidation processes.

References

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Sep 27, 2005·Physiology & Behavior·Eduardo Ekman SchenbergMaria Gabriela Menezes Oliveira
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Citations

Jul 26, 2011·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·E A TsvetkovN P Veselkin
Mar 19, 2009·Neurobiology of Learning and Memory·Rosemary C BagotMarian Joëls
Sep 10, 2009·Hippocampus·Charlis RainekiRegina M Sullivan
Dec 8, 2010·British Journal of Pharmacology·Wei WangJian-Guo Chen
Mar 6, 2013·Hippocampus·Cesar Augusto de Oliveira CoelhoMaria Gabriela Menezes Oliveira
Dec 1, 2012·Hippocampus·Jonathan L C Lee, Robert E Hynds
Sep 2, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Denise R S FabriLeonardo B M Resstel
Jun 16, 2015·Frontiers in Behavioral Neuroscience·Franklin B KrasneMichael S Fanselow
May 20, 2016·Physiology & Behavior·Ricardo CossioGabrielle B Britton
Sep 17, 2016·Neurobiology of Learning and Memory·Alo C BasuJoseph T Coyle
Jan 31, 2017·Frontiers in Behavioral Neuroscience·Magali C CercatoMaría V Baez

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