Feb 1, 1976

Effects of pregnancy on the development of acute uremic syndrome in the rat

Israel Journal of Medical Sciences
M Nitzan, J Klipper-Orbach

Abstract

We evaluated the contributory role which gestational metabolic adaptions may play in the development of acute uremic syndrome in rats by studying the effects of nephrectomy in pregnant and nonpregnant animals. Whereas no significant differences in creatinine and uric acid concentrations were found between control and pregnant rats, urea concentrations were significantly lower in the pregnant animals before, as well as well as 6, 12 and 24 h after, bilateral nephrectomy. It is suggested that creatinine production, which is related to muscle mass, is not altered during late gestation, whereas urea synthesis, which is affected by catabolic and anabolic factors, is significantly reduced.

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Mentioned in this Paper

Metabolic Process, Cellular
Chloride Ion Level
Creatinine
Carmol
AS 6
Urate
Potassium
Nephrectomy
Catabolic Process
Acute Disease

About this Paper

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