Effects of prenatal betamethasone exposure on regulation of stress physiology in healthy premature infants

Psychoneuroendocrinology
Elysia Poggi DavisR C Lussky

Abstract

The objective of this study was to examine the effects of prenatal exposure to betamethasone, a corticosteroid, on postnatal stress regulation, particularly activity of the hypothalamic-pituitary-adrenocortical (HPA) axis. Effects were assessed by measuring salivary cortisol production at baseline and in response to two potentially stressful events, a heel-stick blood draw and a physical exam, in infants born at 33-34 weeks gestation. Subjects included 9 infants with antenatal betamethasone treatment (2 doses of 12 mg of betamethasone administered intramuscularly to the mother twelve hours apart) and 9 infants without such treatment. Testing took place 3-6 days after delivery. Measures of behavioral distress confirmed that both events were stressful to these premature infants. Infants with betamethasone exposure, however, failed to exhibit increases in cortisol to either stressor. In contrast, infants without betamethasone exposure displayed elevated cortisol to the heel-stick blood draw but not the physical exam. These findings suggest that antenatal corticosteroids suppress infants' HPA response to a stressor typically encountered in a neonatal intensive care situation.

References

Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·R A DressendörferC J Strasburger
Mar 1, 1992·Developmental Psychobiology·C L MagnanoB Z Karmel
Nov 1, 1991·Developmental Psychobiology·M R GunnarJ Rigatuso
Jan 1, 1989·Neuropsychobiology·C Kirschbaum, D H Hellhammer
Jan 1, 1989·New Directions for Child Development·M R Gunnar
May 1, 1989·The Journal of Clinical Endocrinology and Metabolism·H G DörrD Knorr
Jul 1, 1995·American Journal of Obstetrics and Gynecology·P A Crowley
Dec 29, 1995·Annals of the New York Academy of Sciences·C A Stratakis, G P Chrousos
Feb 1, 1996·American Journal of Obstetrics and Gynecology·C R ParkerW W Andrews
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·L K Takahashi
Feb 12, 1999·Hormone Research·M BettendorfC Maser-Gluth
Mar 10, 2000·Pediatric Research·S G Matthews
Apr 30, 2002·Obstetrics and Gynecology·UNKNOWN Committee on Obstetric Practice
Oct 10, 2002·Biological Psychiatry·Daniel Pine, Dennis Charney
Dec 1, 2001·Stress : the International Journal on the Biology of Stress·A M Ward, D I Phillips

❮ Previous
Next ❯

Citations

Jan 28, 2014·Current Opinion in Obstetrics & Gynecology·Ewa Romejko-WolniewiczKrzysztof Czajkowski
Apr 23, 2009·Obstetrics and Gynecology·Leonhard SchäfferErnst Beinder
May 28, 2014·Nature Reviews. Endocrinology·Vasilis G Moisiadis, Stephen G Matthews
Feb 10, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·E P DavisM K Georgieff
May 31, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·S W Aucott
May 13, 2009·Journal of Developmental and Behavioral Pediatrics : JDBP·Anna I WagnerH Hill Goldsmith
Mar 23, 2007·Neonatology·Beth L PinelesElysia Poggi Davis
Apr 22, 2008·Expert Opinion on Pharmacotherapy·K Y Ronald Kam, Ronald F Lamont
Dec 26, 2012·Psychoneuroendocrinology·Katherine R GreyLaura M Glynn
Nov 3, 2010·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Joshua R MannMyriam Torres
Jan 15, 2016·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Bjoern B BurckhardtStephanie Läer
May 22, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Elysia Poggi DavisCurt A Sandman
Jan 31, 2007·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Alex PolyakovEuan M Wallace
Nov 18, 2006·Developmental Psychobiology·Anu-Katriina PesonenAnna-Liisa Järvenpää
Feb 8, 2011·Developmental Psychobiology·Elysia Poggi DavisCurt A Sandman
Aug 30, 2012·Acta Paediatrica·Katrin IvarsEvalotte Mörelius
Apr 9, 2005·Early Human Development·Liisa HolstiMichael F Whitfield
Jun 13, 2006·Lancet·Sven Montan, Sabaratnam Arulkumaran
May 9, 2006·Early Human Development·Eva MöhlerFranz Resch
Mar 2, 2006·Early Human Development·Evalotte MöreliusNina Nelson
Mar 22, 2016·International Journal of Environmental Research and Public Health·Evalotte MöreliusShefaly Shorey
Dec 24, 2011·American Journal of Obstetrics and Gynecology·Matthias SchwabPeter W Nathanielsz
Mar 22, 2015·Neuroscience and Biobehavioral Reviews·Maartje A C ZijlmansCarolina de Weerth
Jan 24, 2012·Psychoneuroendocrinology·Elysia Poggi Davis, Curt A Sandman
Jan 31, 2012·Early Human Development·Evalotte MöreliusAnnica Örtenstrand
May 22, 2018·The Journal of Perinatal & Neonatal Nursing·Patrícia de FreitasAmélia Fumiko Kimura
Sep 15, 2018·The Journal of Clinical Endocrinology and Metabolism·Danielle A SwalesElysia Poggi Davis
Mar 30, 2019·Development and Psychopathology·Kristie L PooleLouis A Schmidt
Apr 12, 2016·Development and Psychopathology·Daniel BerryUNKNOWN Family Life Project Key Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.