Effects of prenatal cocaine exposure on adolescent development

Neurotoxicology and Teratology
Gale A RichardsonNancy L Day

Abstract

The associations between prenatal cocaine exposure (PCE) and adolescent behavior, cognitive development, and physical growth were examined in 219 15-year-olds who have participated in a longitudinal study since their fourth gestational month. During the first trimester, 42% of the women used cocaine, with use declining across pregnancy. At the 15-year follow-up, the caregivers were, on average, 43 years old, had 13 years of education, and 50% were African American. First trimester PCE was not associated with global cognitive development or with measures of learning and memory. First trimester PCE was significantly related to adolescent-reported delinquent behavior, poorer problem solving and abstract reasoning, and reduced weight, height, and head circumference at 15 years. These results were significant after other factors that affect these domains were controlled in regression analyses. In addition, exposure to violence partially mediated the effect of PCE on delinquent behavior. These adolescent domains are important because they are predictors of poorer adult functioning.

References

Jun 1, 1978·Journal of Health and Social Behavior·B S DohrenwendB P Dohrenwend
Sep 1, 1992·Journal of Child Psychology and Psychiatry, and Allied Disciplines·F C Verhulst, J van der Ende
Jan 1, 1991·The American Journal of Drug and Alcohol Abuse·V Johnson, R J Pandina
Jan 1, 1989·Annals of the New York Academy of Sciences·N L Day, N Robles
Oct 1, 1970·Journal of Educational Psychology·E Gaudry, C D Spielberger
Jan 1, 1983·Experimental Brain Research·S A Bayer
Feb 1, 1984·Child Development·L A Sroufe, M Rutter
Aug 1, 1982·Obstetrical & Gynecological Survey·J Villar, J M Belizan
Aug 1, 1980·Journal of Abnormal Psychology·S A WolchikM Mavissakalian
Dec 31, 1997·Archives of Pediatrics & Adolescent Medicine·H HurtJ Giannetta
Oct 4, 2000·Pediatrics·V Delaney-BlackR J Sokol
Mar 23, 2002·Journal of Pediatric Psychology·Veronica H AccorneroJames C Anthony
May 16, 2002·Neurotoxicology and Teratology·Emmalee S BandstraJames C Anthony
Jul 20, 2002·Neurotoxicology and Teratology·Chandice Y CovingtonVirginia Delaney-Black
Oct 28, 2003·Journal of Developmental and Behavioral Pediatrics : JDBP·Margaret BenderskyMichael Lewis
Apr 15, 2004·Journal of Developmental and Behavioral Pediatrics : JDBP·Robert E ArendtDaniel Flannery
May 27, 2004·JAMA : the Journal of the American Medical Association·Lynn T SingerH Lester Kirchner
Sep 7, 2004·Journal of Pediatric Psychology·Connie E MorrowEmmalee S Bandstra
Feb 1, 2005·Neurotoxicology and Teratology·Deborah A FrankHoward Cabral
Mar 1, 2005·Neurotoxicology and Teratology·Beth Nordstrom BaileyVirginia Delaney-Black
Mar 1, 2005·Neurotoxicology and Teratology·Beena G SoodVirginia Delaney-Black
Apr 2, 2005·Journal of Pediatric Psychology·Teresa J LinaresSonia Minnes
Jun 9, 2005·Neurotoxicology and Teratology·Julia S NolandCynthia Bearer
Aug 23, 2005·Neurotoxicology and Teratology·Linda C MayesNicole C Hunter
Nov 22, 2005·Neurotoxicology and Teratology·Sonia MinnesLynn T Singer
May 10, 2006·Journal of Developmental and Behavioral Pediatrics : JDBP·Tamara Duckworth WarnerFonda Davis Eyler
Nov 7, 2006·Developmental Neuropsychology·Connie E MorrowEmmalee S Bandstra
Apr 7, 2007·Neurotoxicology and Teratology·Julie C LumengDeborah A Frank
Apr 25, 2007·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Linda MayesNicole Hunter
Jun 15, 2007·Journal of Developmental and Behavioral Pediatrics : JDBP·Veronica H AccorneroEmmalee S Bandstra
Sep 22, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Sandhya RamrakhaAvshalom Caspi
Nov 6, 2007·Drug and Alcohol Dependence·Elaine Eggleston DohertyMargaret E Ensminger
Dec 20, 2007·Journal of Developmental and Behavioral Pediatrics : JDBP·David BennettMichael Lewis
Feb 5, 2008·Neurotoxicology and Teratology·Gale A RichardsonJennifer Willford
Mar 20, 2008·Journal of Developmental and Behavioral Pediatrics : JDBP·Henrietta S BadaPenelope L Maza
Jun 24, 2008·The Journal of Pediatrics·Lynn T SingerSonia Minnes
Jan 17, 2009·Neurotoxicology and Teratology·Ruth Rose-JacobsDeborah A Frank

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Citations

Sep 21, 2015·Current Psychiatry Reports·Ariadna Forray, Dawn Foster
Jul 6, 2015·Neurotoxicology and Teratology·Lauren Pemberton, Carl L Hart
Jul 5, 2015·Neurotoxicology and Teratology·Gale A RichardsonNancy L Day
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Lynne M Smith, Lucinda S Santos
Jun 4, 2016·International Journal of Molecular Sciences·Eric J MersereauTristan Darland
Mar 31, 2018·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Brandi P CottonLinda L LaGasse
Jan 3, 2019·Clinical Obstetrics and Gynecology·Marcela C SmidAdam J Gordon
Aug 6, 2019·Frontiers in Cell and Developmental Biology·Hye M HwangKazue Hashimoto-Torii
Jul 8, 2020·Infancy : the Official Journal of the International Society on Infant Studies·Irene TungJill M Waterman
Jul 29, 2021·Adversity and Resilience Science·Lynn T SingerJulie Kable
Oct 15, 2021·Neurotoxicology and Teratology·Natalia KarpovaMichael Lewis

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