Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases: The Hokkaido Study on Environment and Children's Health

The Science of the Total Environment
Yu Ait BamaiReiko Kishi

Abstract

Phthalates are widely used in consumer products, and experimental studies suggest that exposure to phthalates increase the risk of allergies. However, epidemiologic evidence on the associations between prenatal phthalate exposure and allergies/infectious diseases and cord blood immunoglobulin E (IgE) levels is limited. This study aimed to evaluate the associations between maternal mono(2-ethylhexyl) phthalate (MEHP) levels and cord blood IgE levels at birth (n=127), as well as the risk of allergies/infectious diseases in participants up to 7years of age; the participants were 1.5 (n=248), 3.5 (n=222), 7 (n=184) years of age. Maternal blood MEHP level in the second trimester was measured using gas chromatography-mass spectrometry. Participant characteristics were obtained from the medical birth records and self-administered questionnaires during pregnancy and after delivery. Wheeze and eczema were defined according to the Japanese version of the International Study of Asthma and Allergies in Childhood and the American Thoracic Society-Division of Lung Diseases questionnaire, respectively. Infectious diseases were defined using questionnaires for each specified age. To evaluate the associations between maternal MEHP and allergies...Continue Reading

Citations

Feb 19, 2019·Food Additives & Contaminants. Part B, Surveillance·Jinling YangChengjun Sun
Mar 15, 2020·Environmental Health : a Global Access Science Source·Camilla JøhnkTina Kold Jensen
Dec 14, 2019·Toxicologic Pathology·Scott M BelcherJeffrey C Wolf
Sep 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Emily MackeyAdam J Moeser
Aug 28, 2020·Environment International·Berit GranumMartine Vrijheid
Jan 30, 2021·Environmental Science and Pollution Research International·Chih-Wen WangChao-Hung Kuo
May 1, 2021·International Journal of Environmental Research and Public Health·Azahara María García-SernaEva Morales
May 24, 2021·Environmental Health and Preventive Medicine·Reiko KishiUNKNOWN members of The Hokkaido Study on Environment and Children’s Health
Jul 3, 2021·International Journal of Environmental Research and Public Health·Chang-Ku TsaiHong-Ren Yu
Jul 1, 2021·Allergy and Asthma Proceedings·Minyoung JungYong Mean Park
Sep 28, 2018·Environmental Science & Technology·Hongzhi ZhaoZongwei Cai
Sep 4, 2021·Journal of Exposure Science & Environmental Epidemiology·Anna-Sofia PreeceHuan Shu

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