PMID: 2496424Jan 1, 1989Paper

Effects of prenatal ethanol exposure in C57BL mice on locomotor activity and passive avoidance behavior

Psychopharmacology
H C Becker, C L Randall

Abstract

The purpose of this study was to examine the long-term behavioral effects of prenatal ethanol exposure in C57BL mice. Pregnant mice received free access to a liquid diet containing 25% ethanol-derived calories (EDC) from gestation days 6 to 18. Control animals were pair-fed an isocaloric 0% EDC diet during the same period of time. An additional control group was included that was maintained on standard lab chow and water throughout pregnancy. At 30 days of age, female offspring were tested for spontaneous locomotor activity in an open field under two lighting conditions (dim or bright illumination). Male offspring were tested in a passive avoidance task at 25 days of age. The activity results demonstrated that the 25% EDC female progeny were more active than controls. This hyperactivity was observed under both lighting conditions, despite the fact that all groups evidenced suppressed activity when tested under bright lights. With regard to passive avoidance behavior, male EtOH-exposed offspring required a greater number of trials to reach criterion than controls. Additionally, they exhibited shorter latencies to enter the shock-associated chamber after receiving a single shock. Taken together, these results confirm our previous...Continue Reading

References

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Citations

Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·K B KumarK S Karanth
Nov 1, 1993·Neurotoxicology and Teratology·M P HandeK S Karanth
Sep 1, 1995·Neurotoxicology and Teratology·P ClausingM G Paule
Jun 13, 2013·Behavioural Brain Research·Michelle C Sanchez VegaThomas H J Burne
Jan 27, 2004·Brain Research. Developmental Brain Research·C J Malanga, Barry E Kosofsky
Dec 1, 1996·Pharmacology, Biochemistry, and Behavior·H C BeckerC L Randall
Aug 26, 1998·Drug and Alcohol Dependence·P Levitt
Nov 24, 1999·Neurotoxicology and Teratology·A H Nagahara, R J Handa
Oct 16, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Chris DowningDavid Gilliam
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·J A OsbornJ Weinberg
Apr 1, 1996·Environmental Health Perspectives·G Bignami
May 24, 2011·Behavioural Brain Research·Morgan L KleiberShiva M Singh
Apr 30, 2019·Birth Defects Research·Shama BhatiaPeter G Wells

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