Effects of prenatal stress and exercise on dentate granule cells maturation and spatial memory in adolescent mice

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Carlos BustamanteRodrigo Pascual

Abstract

Exposure to prenatal stress (PS) increases the risk of developing neurobehavioral disturbances later in life. Previous work has shown that exercise can exert beneficial effects on brain damage; however, it is unknown whether voluntary wheel running (VWR) can ameliorate the neurobehavioral impairments induced by PS in adolescent offspring. Pregnant CF-1 mice were randomly assigned to control (n=5) or stressed (n=5) groups. Pregnant dams were subjected to restraint stress between gestational days 14 and 21 (G14-21), whereas controls remained undisturbed in their home cages. On postnatal day 21 (P21), male pups were randomly assigned to the following experimental groups: control (n=5), stressed (n=5), and stressed mice+daily submitted to VWR (n=4). At P52, all groups were behaviorally evaluated in the Morris water maze. Animals were then sacrificed, and Golgi-impregnated granule cells were morphometrically analyzed. The results indicate that PS produced significant behavioral and neuronal impairments in adolescent offspring and that VWR significantly offset these deleterious effects.

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Citations

Mar 8, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Carlos BustamanteRodrigo Pascual
Nov 23, 2012·The Journal of Comparative Neurology·Julie A MarkhamJames I Koenig
Jun 10, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Curtis E GraceJohn M Rogers
Apr 19, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Rodrigo PascualCarlos Bustamante
Jun 20, 2015·BioMed Research International·Kin-ya KuboHuayue Chen
Jun 4, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cristian Gutiérrez-RojasCarlos Bustamante
Jun 29, 2012·Neurobiology of Aging·Annerieke S R SierksmaDaniel L A van den Hove
Jul 27, 2014·Journal of Neuroscience Methods·Sareesh Naduvil NarayananP Gopalakrishna Bhat
Jan 18, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Igor PanticClaude Brodski
Feb 17, 2017·Clinical Pediatric Endocrinology : Case Reports and Clinical Investigations : Official Journal of the Japanese Society for Pediatric Endocrinology·Rodrigo PascualMartina Valencia
May 8, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Luis E B BettioJoana Gil-Mohapel

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