Effects of preoperative aspirin in coronary artery bypass grafting: a double-blind, placebo-controlled, randomized trial

The Journal of Thoracic and Cardiovascular Surgery
Marek A DejaStanisław Woś

Abstract

This trial was undertaken to determine the safety and efficacy of preoperative aspirin administration in a contemporary cardiac surgical practice setting. This randomized, double-blind, parallel-group, single-center trial involved patients with stable coronary artery disease who were assigned to receive either 300 mg of aspirin or placebo the night before coronary bypass surgery. Using a random digit table, patients were allocated to receive the tablet from 1 of the 40 coded bottles containing either aspirin or placebo. Patients, surgeons, anesthetists, and investigators were all masked to treatment allocation. The primary safety end points were as follows: more than 750 mL of bleeding during the first postoperative 12 hours and more than 1000 mL of total discharge from the chest drains. The secondary efficacy end point was a composite of cardiovascular death, myocardial infarction, or repeat revascularization. A total of 390 patients were allocated to aspirin (387 analyzed) and 399 to placebo (396 analyzed). The follow-up median was 53 months. Fifty-four placebo recipients and 86 aspirin recipients bled more than 750 mL in the first 12 hours (odds ratio [OR], 1.81; 95% confidence interval [CI], 1.25-2.63), while total chest dr...Continue Reading

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Citations

Mar 8, 2013·Thrombosis and Haemostasis·E L GroveR F Storey
Apr 22, 2014·European Heart Journal·Miguel Sousa-UvaUNKNOWN ESC Working Group on Cardiovascular Surgery and ESC Working Group on Thrombosis
Oct 20, 2012·The Journal of Thoracic and Cardiovascular Surgery·Tomislav KopjarMate Petričević
Sep 15, 2014·The Journal of Thoracic and Cardiovascular Surgery·Richard D WeiselUNKNOWN RED-CABG Executive and Steering Committees
Jun 18, 2015·British Journal of Anaesthesia·S HastingsD McIlroy
Dec 21, 2014·Seminars in Thoracic and Cardiovascular Surgery·Victor A Ferraris, Michael D Bolanos
Sep 4, 2016·Surgery·Rustin KashaniPeyman Benharash
Oct 6, 2016·Interactive Cardiovascular and Thoracic Surgery·Sleiman Sebastian Aboul-HassanRomuald Cichon
Nov 11, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Anjan TibrewalaAkinobu Itoh
Sep 4, 2016·Scandinavian Cardiovascular Journal : SCJ·Emma C Hansson, Anders Jeppsson
Oct 14, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Miguel Sousa-UvaUlf Landmesser
Dec 6, 2017·Journal of Cardiac Surgery·Sleiman Sebastian Aboul-HassanRomuald Cichon
Oct 14, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Domenico PaganoChrista Boer
Aug 19, 2015·Journal of the American Heart Association·Michael GoldfarbJonathan Afilalo
Jan 18, 2019·Journal of Veterinary Emergency and Critical Care·Benjamin M BrainardElizabeth A Rozanski
Sep 28, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Michel Pompeu Barros Oliveira SáRicardo Carvalho Lima
Feb 19, 2017·Current Cardiology Reports·Ayman ElbadawiRamez Nairooz
Nov 18, 2018·The Journal of Thoracic and Cardiovascular Surgery·John Bozinovski
Nov 8, 2018·The Journal of Thoracic and Cardiovascular Surgery·Paul S MylesUNKNOWN ATACAS investigators and the ANZCA Clinical Trials Network

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