PMID: 8595645Sep 1, 1995Paper

Effects of preoperative chemotherapy on gastric carcinoma: the relationship between histopathologic response and prognosis

Clinical Therapeutics
K KumagaiA Yasui

Abstract

To evaluate the efficacy of preoperative chemotherapy in the treatment of gastric carcinoma, 48 previously untreated patients with locoregional advanced gastric carcinoma were consecutively enrolled in this study and received preoperative 5-fluorouracil (5-FU) or 5'-deoxy-5- fluorouridine (5'-DFUR). Histopathologically, 17 patients showed no response, 27 responded slightly, 3 moderately, and 1 had an excellent response to the chemotherapy. Based on clinical cancer staging, the overall 5-year survival rate was 79% in patients with stages IB and II cancer, 44% in patients with stage III cancer, and 14% in those with stage IV cancer. In patients with stages IB, II, and IIIA disease, the 5-year survival rate for those with a positive histopathologic response to the chemotherapy was 74%, whereas that for the nonresponders was 45%. No relationship was seen between the grade of the histopathologic response and the 5-year survival rate of patients with stage IIIB and IV carcinoma. In a second group of 27 patients who received preoperative chemotherapy with 5-FU, the effect of 5-FU was evaluated using thymidylate synthetase (TS) inhibition. Free TS and total TS were measured in the tumor samples, and the thymidylate synthetase inhibitio...Continue Reading

References

Oct 1, 1991·Anti-cancer Drugs·M LiseA Fornasiero
May 1, 1984·Annals of Surgery·K J CarterW P Ritchie
Nov 1, 1981·American Journal of Surgery·N KaibaraS Fukumoto

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Citations

Aug 26, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D D'UgoR Ricci

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