Effects of preservation on the osteoinductive capacity of demineralized bone powder allografts

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
M HosnyM Sharawy

Abstract

Demineralized bone powder (DBP) has repeatedly been shown to serve as an osteoinductive material. The aim of this study was to investigate the effects of different methods of storage of DBP on its osteoinductive property. Forty-five Long Evan rats were used in this study. Twenty rats were used as donors; the diaphyses of their femoral bones were used for the preparation of DBP. The DBP was divided into four portions that were either lyophilized or frozen at -70 degrees C, -4 degrees C, or kept at room temperature (25 degrees C). All samples were stored under the specified condition for six months. At the time of implantation, fresh DBP was prepared and used as a control. Twenty-five rats were divided equally into five groups. Each group received an implant of either one of the differently preserved and stored samples of DBP or fresh DBP. The animals were killed 60 days following implantation. The implants were excised and processed to obtain 5 micron thick decalcified sections and 3 micron thick undecalcified sections. Semicomputerized histomorphometry was used for the quantification of the newly-formed bone in each implant. Newly-formed bone was detected in all experimental and control groups and there were no statistically si...Continue Reading

References

Jun 1, 1976·The Journal of Cell Biology·A H Reddi, W A Anderson
Nov 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Hosny, M Sharawy
Dec 1, 1985·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M Hosny, M Sharawy
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·A H Reddi, C Huggins
Jul 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A H Reddi, C B Huggins

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Citations

Oct 1, 1993·Biomaterials·M J DohertyD J Wilson
Dec 20, 2003·Journal of Periodontology·Scott A MatzenbacherMark E Peacock
Apr 4, 2006·Journal of Periodontology·Kurt B FleckensteinJames C McPherson
Oct 9, 2012·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·B AghdasiJ C Wang
Sep 3, 1999·The Orthopedic Clinics of North America·T BoyceN Scarborough

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