PMID: 9168152Apr 26, 1997Paper

Effects of pressure and local anesthetic tetracaine on dipalmitoylphosphatidylcholine bilayers

Biochimica Et Biophysica Acta
S MaruyamaS Kaneshina

Abstract

The temperature-pressure phase diagram of dipalmitoylphosphatidylcholine (DPPC) multilamellar vesicles was constructed in the presence of a local anesthetic tetracaine hydrochloride (TC-HCl). The phase-transition temperatures under various pressures were determined by the method of high-pressure light transmission. The temperature of the main transition from the ripple gel (P'(beta)) to the liquid crystal (L(alpha)) phase was depressed by the addition of TC-HCl and elevated by application of pressure up to 150 MPa. The temperature of the pretransition from the lamellar gel (L'(beta)) to the P'(beta) phase was also depressed by the addition of TC-HCl below ca. 10.0 mmol kg(-1) and elevated by the pressure below ca. 50 MPa. Therefore, pressure-anesthetic antagonism for both phase-transitions was confirmed. The pressure-induced interdigitated gel (L(beta)I) phase has been observed under high pressure above 100 MPa in the absence of TC-HCl. The L(beta)I phase is known to be induced also by a variety of small amphiphilic molecules such as ethanol, benzyl alcohol and TC-HCl. In the presence of TC-HCl ranging in concentration up to 20.0 mmol kg(-1), the L(beta)I phase instead of the P'(beta) phase appeared at higher pressure. Present ...Continue Reading

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S Mabrey, J M Sturtevant
Jun 12, 1987·Biochimica Et Biophysica Acta·D J SiminovitchH H Mantsch
Dec 11, 1987·Biochimica Et Biophysica Acta·D A WilkinsonT J McIntosh

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Citations

Feb 6, 2008·European Biophysics Journal : EBJ·Harpreet SinghMichael R Morrow
Jun 6, 2002·Chemistry and Physics of Lipids·Rumiana Koynova, Martin Caffrey
Jan 6, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·C RömmenB C Lippold
Mar 21, 2007·Biophysical Chemistry·Megan D ReevesPhoebe Dea
Jun 12, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Md Nasir Uddin, Michael R Morrow

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