PMID: 22574563May 12, 2012Paper

Effects of preventive-electroacupuncture of "Guanyuan" (CV 4) and "Sanyinjiao" (SP 6) on hypothalamus-pituitary-ovary axis in ovariectomized rats

Zhen ci yan jiu = Acupuncture research
Kai Cheng, Su-Ling Tian

Abstract

To observe the effect of preventive-electroacupuncture (PEA) at "Guanyuan" (CV 4) and "Sanyinjiao" (SP 6)on hypothalamus-pituitary-ovary (HPO)activities in ovariectomized (OVX) rats, and to compare the specificity of efficacy of acupoints. Sixty-two female SD rats were randomly divided into normal group (n = 6), sham-operation (sham) group (n = 6), model group (n = 6), PEA-Guanyuan (CV 4, PEA-CV 4) group (n = 11), PEA-Sanyinjiao (SP 6, PEA-SP 6) group (n = 11), complementary (C)-PEA-CV 4 (n = 11) and C-PEA-SP 6 group (n = 11). Climacterium model was duplicated by removing the bilateral ovaries. Before OVX, electroacupuncture (EA, 2 Hz/100 Hz, ) was applied to bilateral SP 6, CV 4 for 20 min, once every other day for 15 times. For rats of the C-PEA-CV 4 and C-PEA-SP 6 groups and 12 days after the OVX, PEA was applied to CV 4 and SP 6 again, once every other day for 5 times. For rats of the sham group, a little of fat nearby the ovary was removed. Enzyme-linked immunosorbent assay was used to measure the contents of gonadotropin releasing hormone (GnRH) in the hypothalamus, follicule-stimulating hormone (FSH) and luteinizing hormone (LH) in the hypophysis, and estrogen (E2) in the uterus. In comparison with the normal group, uter...Continue Reading

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