Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors

Toxicology Letters
Hiroyuki KojimaAdrian Covaci

Abstract

Organophosphate flame retardants (OPFRs) have been used in a wide variety of applications and detected in several environmental matrices, including indoor air and dust. Continuous human exposure to these chemicals is of growing concern. In this study, the agonistic and/or antagonistic activities of 12 primary OPFR-metabolites against ten human nuclear receptors were examined using cell-based transcriptional assays, and compared to those of their parent compounds. As a result, 3-hydroxylphenyl diphenyl phosphate and 4-hydroxylphenyl diphenyl phosphate showed more potent estrogen receptor α (ERα) and ERβ agonistic activity than did their parent, triphenyl phosphate (TPHP). In addition, these hydroxylated TPHP-metabolites also showed ERβ antagonistic activity at higher concentrations and exhibited pregnane X receptor (PXR) agonistic activity as well as androgen receptor (AR) and glucocorticoid receptor (GR) antagonistic activities at similar levels to those of TPHP. Bis(2-butoxyethyl) 3'-hydroxy-2-butoxyethyl phosphate and 2-hydroxyethyl bis(2-butoxyethyl) phosphate act as PXR agonists at similar levels to their parent, tris(2-butoxyethyl) phosphate. On the other hand, seven diester OPFR-metabolites and 1-hydroxy-2-propyl bis(1-ch...Continue Reading

References

Mar 15, 1981·Toxicology and Applied Pharmacology·A A NomeirH B Matthews
Oct 26, 2000·Environmental Health Perspectives·UNKNOWN World Health Organization
Oct 19, 2004·Chemosphere·Paul C HartmannWalter Giger
Dec 17, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sundaram ArulmozhirajaMasatoshi Morita
Feb 8, 2005·Toxicology·Shigeyuki KitamuraNariaki Fujimoto
Jan 6, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Birgit Karin SchindlerJürgen Angerer
Feb 3, 2009·Environment International·Hidetaka TakigamiShin-ichi Sakai
Feb 22, 2011·The Science of the Total Environment·Thorsten ReemtsmaStefanie Roegler
Nov 29, 2012·Environmental Science & Technology·Heather M StapletonArlene Blum
Mar 26, 2013·Environment International·Courtney C CarignanThomas F Webster
Dec 10, 2013·Environment International·Kate HoffmanHeather M Stapleton
Feb 18, 2014·The Science of the Total Environment·Shuji TajimaReiko Kishi
Jul 26, 2014·Environmental Health Perspectives·Hari K PillaiJennifer J Schlezinger
Jan 21, 2015·Analytical and Bioanalytical Chemistry·Mohamed Abou-Elwafa AbdallahStuart Harrad
Feb 15, 2015·Toxicology and Applied Pharmacology·Nele Van den EedeAdrian Covaci
Feb 19, 2015·Environmental Science & Technology·Ana Ballesteros-GómezAdrian Covaci

❮ Previous
Next ❯

Citations

Mar 17, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Boris V KrivoshievSteven J Husson
Aug 11, 2016·Toxicology Letters·Darja Gramec SkledarLucija Peterlin Mašič
Oct 22, 2016·Environmental Science & Technology·Nele Van den EedeAdrian Covaci
Apr 22, 2017·Environmental Science & Technology·Quan ZhangMeirong Zhao
Jun 5, 2020·Journal of Applied Toxicology : JAT·Rie YanagisawaHirohisa Takano
Nov 21, 2018·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Zhiqiang FuHongbin Xie
May 1, 2021·International Journal of Molecular Sciences·Chander K NegiLuděk Bláha
Jun 5, 2021·Environmental Pollution·Joana FeiteiroElisa Cairrão
Aug 12, 2021·Environmental Science and Pollution Research International·Tadiyose Girma BekeleAbdul Qadeer
Nov 11, 2017·Environmental Science & Technology·Weining WanShuzhen Zhang
Mar 14, 2019·Environmental Science & Technology·Constance A MitchellDavid C Volz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.