Effects of printing-induced interfaces on localized strain within 3D printed hydrogel structures

Materials Science & Engineering. C, Materials for Biological Applications
Kyle ChristensenYong Huang

Abstract

Additive manufacturing, or 3D printing, is a promising approach for the fabrication of biological structures for regenerative medicine applications using tissue-like materials such as hydrogels. Herein, inkjet printing is implemented as a model droplet-based 3D printing technology for which interfaces have been shown to form between printed lines within printed layers of hydrogel structures. Experimental samples with interfaces in two orientations are fabricated by inkjet printing and control samples with and without interfaces are fabricated by extrusion printing and casting, respectively. The formation of partial and full interfaces is modeled in terms of printing conditions and gelation parameters, and an approach to predicting the ratio of interfacial area to the total contact area between two adjacent lines is presented. Digital image correlation is used to determine strain distributions and identify regions of increased localized deformation for samples under uniaxial tension. Despite the presence of interfaces in inkjet-printed samples, strain distributions are found to be homogeneous regardless of interface orientation, which may be attributed to the multi-layer nature of samples. Conversely, single-layer extrusion-prin...Continue Reading

References

Jan 23, 1999·Biomaterials·J A RowleyD J Mooney
Nov 15, 2000·Journal of Biomedical Materials Research·T A BeckerT Brandon
Feb 26, 2004·Biomaterials·Jeanie L DruryDavid J Mooney
Jul 25, 2007·Journal of Biomedical Materials Research. Part a·Catherine K Kuo, Peter X Ma
Mar 1, 2011·Analytical Chemistry·Thomas BraschlerPhilippe Renaud
Jul 7, 2012·Biotechnology and Bioengineering·Changxue XuRoger R Markwald
Sep 28, 2012·Journal of Biomedical Materials Research. Part a·Bin DuanJonathan T Butcher
May 21, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Georgia KaklamaniJames Bowen
Dec 24, 2015·Biofabrication·Ruitong XiongDouglas B Chrisey
May 24, 2017·ACS Applied Materials & Interfaces·Yifei JinYong Huang
Sep 4, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Yifei JinYong Huang

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Citations

Aug 31, 2018·Advanced Materials·Mohamadreza MoiniPablo D Zavattieri
Oct 16, 2018·Frontiers in Chemistry·Guiting LiuZhipeng Gu
Apr 28, 2020·ACS Applied Materials & Interfaces·Kaidong SongYong Huang

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