Effects of prior experience on differential learning under amphetamine.

Psychopharmacologia
D M Grilly

Abstract

Differential learning of operant behavior under non-drug and amphetamine states was explained with a "drug-behavior-reinforcement interaction" process. When a drug affects the relationship between ongoing behavior and existing reinforcement contingencies, the sets of behavioral patterns subjected to the process of reinforcement or non-reinforcement under a drug may differ from the patterns under non-drug conditions. If, following sufficient training, the drug conditions are then changed, persistence of these behavioral patterns may result in a difference from those patterns produced if acquisition occurs solely under non-drug conditions. To investigate this process, groups of rats were given varying amounts of non-drug acquisition training on a response-duration differentiation task before being given extended training under 0.75 mg/kg d-amphetamine. All groups were then tested under non-drug conditions. Amphetamine significantly enhanced performance, and this enhancement transferred to subsequent non-drug conditions. However, if non-drug training occurred before drug training, this enhancement was greatly attenuated. Furthermore, only those behavioral components under which amphetamine led to an increase in reinforcement rate ...Continue Reading

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Citations

Jan 1, 1981·Psychopharmacology·D M GrillyJ P Dugovics
Jan 29, 2002·Pharmacology, Biochemistry, and Behavior·Alasdair M Barr, Anthony G Phillips
Oct 1, 1984·The Journal of General Psychology·S H EvansF H Gage

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