PMID: 2502793Jan 1, 1989Paper

Effects of prior saline-morphine discrimination by pigeons on three-way discrimination including two morphine doses

Psychopharmacology
D V Gauvin, A M Young

Abstract

The discriminative stimulus properties of morphine sulfate (MS) and their alteration by naltrexone (NTX) and d-amphetamine (AMP) challenges were examined in a quantitative dose 1, dose 2, and saline (SAL) drug discrimination task utilizing 1.8 mg/kg MS, 10 mg/kg MS, and SAL as discriminative stimuli under a fixed-ratio 30 schedule of food-maintained behavior in two groups of White Carneaux pigeons. Group A (Gp A) (n = 6) subjects (Ss) were initially experimentally- and drug-naive, whereas group B Ss (n = 4) were originally trained in a two-choice MS versus SAL discrimination task, and had a long behavioral and drug history. Significant differences were found in (1) number of sessions to criterion (STC) (group B greater than group A); (2) group A Ss generalized both NTX and AMP to SAL, whereas group B Ss generalized AMP to the low dose (1.8 mg/kg) MS stimulus; and (3) in drug interaction test sessions, the high dose MS stimulus (10 mg/kg) in group A was unmodified by a range of challenge AMP doses (0.32 to 3.2 mg/kg). In contrast, group B Ss exhibited a shift to the low dose or SAL-appropriate keys when the same high dose MS stimulus was challenged by moderate doses of AMP. Group A and group B were similar in their pattern and d...Continue Reading

References

Nov 1, 1977·Pharmacology, Biochemistry, and Behavior·M R Leberer, S C Fowler
Jan 1, 1989·Psychopharmacology·D V Gauvin, A M Young
Oct 1, 1984·European Journal of Pharmacology·S HerlingJ H Woods
Jan 1, 1983·Psychopharmacology·J M White, S G Holtzman
May 1, 1984·Pharmacology, Biochemistry, and Behavior·E C KrimmerH Barry
Mar 1, 1981·Neuropharmacology·R J Barrett, N J Leith

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Citations

Jan 1, 1989·Psychopharmacology·D V Gauvin, A M Young
Jan 1, 1990·Psychopharmacology·A M YoungL E Tetrick
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·M GaiardiM Babbini
Apr 1, 1994·Drug and Alcohol Dependence·E A Mariathasan, I P Stolerman
Feb 22, 2002·Behavioural Pharmacology·M Li, D E McMillan
May 10, 2021·Journal of Pharmacological and Toxicological Methods·David V Gauvin, Zachary J Zimmermann

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