Effects of probenecid and cimetidine on renal disposition of ofloxacin in rats.

Antimicrobial Agents and Chemotherapy
E F Foote, C E Halstenson

Abstract

The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin is secreted by both the anionic and cationic transport systems.

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Citations

Aug 21, 2002·Biological & Pharmaceutical Bulletin·Qiuhong LiKikuo Iwamoto
Apr 30, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tsuyoshi MinematsuHidetaka Kamimura
Feb 18, 2017·Clinical Pharmacokinetics·Anton IvanyukThierry Buclin
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