PMID: 8473652May 1, 1993Paper

Effects of procainamide on the signal-averaged electrocardiogram in relation to the results of programmed ventricular stimulation in patients with sustained monomorphic ventricular tachycardia

Journal of the American College of Cardiology
P KulakowskiA J Camm

Abstract

The aim of this study was to assess the ability of the signal-averaged electrocardiogram (ECG) to predict the efficacy of procainamide. The main role of the signal-averaged ECG has been the identification of postinfarction patients at risk of sudden death. Prediction of the efficacy of antiarrhythmic drugs represents another potential clinical application of this technique. The study examined the effects of procainamide on the time domain and spectral temporal analysis of the signal-averaged ECG in relation to the results of programmed ventricular stimulation studies in 31 patients with inducible sustained monomorphic ventricular tachycardia. Procainamide significantly prolonged the total and the initial QRS complex and low amplitude signal durations (mean +/- SD 135 +/- 30 vs. 161 +/- 46 ms, p < 0.0001; 87 +/- 16 vs. 98 +/- 20 ms, p < 0.0001, and 48 +/- 23 vs. 63 +/- 36 ms, p < 0.001, respectively) whereas the root-mean-square voltage of the total QRS complex and of the last 40 ms of the QRS complex was significantly reduced (mean +/- SD 112 +/- 36 vs. 87 +/- 36 microV, p < 0.0001; 21 +/- 19 vs. 13 +/- 12 microV, p < 0.002, respectively). The results of spectral temporal mapping of the signal-averaged ECG were similar before a...Continue Reading

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References

Apr 1, 1978·The American Journal of Cardiology·E J BerbariR Lazzara
Jan 11, 1992·The American Journal of Cardiology·J S SteinbergJ L Fleiss
Dec 1, 1984·Journal of the American College of Cardiology·F E MarchlinskiM E Josephson

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Citations

Apr 19, 1996·International Journal of Cardiology·B MladosievicovaP Hubka
Apr 18, 2002·International Journal of Cardiology·Béatrice Brembilla-PerrotChristine Suty-Selton
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eric S HayesMichael J A Walker
Nov 1, 1994·Pacing and Clinical Electrophysiology : PACE·C TakanakaS Yame
Oct 12, 2018·Pacing and Clinical Electrophysiology : PACE·Piotr FutymaPiotr Kułakowski

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