Effects of profound hypoxemia on coagulation & fibrinolysis in normal individuals

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Daniel T RedfordVance G Nielsen

Abstract

Hypoxia has been proposed to enhance, diminish, or have no effect on laboratory measures of coagulation or clinical thrombosis. Further, there usually are significant pathological or environmental factors concurrently present with hypoxia. Thus, the goal of the present investigation was to determine whether whole blood or plasmatic coagulation and fibrinolytic kinetics would change in response to progressive hypoxia to a systemic oxygenation (SpO2) of 70%. Healthy, conscious volunteers (n = 9) breathing a hypoxic mixture of gases during an in-vivo validation of noninvasive cerebral oximetry had blood samples collected and assessed with thrombelastography at normoxia and after SpO2 of 70%. A mild release of endogenous heparin-like activity occurred that diminished plasmatic coagulation, and a mild increase in clot lysis time also was noted. Further investigation to determine whether these phenomena occur in more chronic, less hypoxic states as sources of hypocoagulation or thrombophilia is needed.

References

Jan 1, 1979·British Heart Journal·P HenrikssonN R Lundström
Jan 4, 2001·Journal of Critical Care·V G Nielsen, B T Geary
Feb 15, 2003·Thrombosis Research·Wolfgang SchobersbergerHanns Christian Gunga
Apr 25, 2006·Thrombosis Research·Wolfgang SchobersbergerWerner Streif
Feb 18, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Marco SenzoloAndrew K Burroughs
Mar 23, 2012·Thrombosis and Haemostasis·Daniel S MartinUNKNOWN Caudwell Xtreme Everest Research Group
Aug 8, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenRyan W Matika

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Citations

Feb 12, 2019·Cardiology in the Young·Arun SainiUmar S Boston
Nov 16, 2018·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Lene RussellAnders Perner

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