Effects of progesterone on prolactin, hypothalamic beta-endorphin, hypothalamic substance P, and midbrain serotonin in guinea pigs

Neuroendocrinology
C L BetheaJ M Henningfeld

Abstract

Unlike rats, but similar to primates, guinea pigs exhibit prolonged function of the corpus luteum and elevated progesterone secretion after ovulation. The gonadotropins, estrogen (E) and progesterone (P) have been examined throughout the guinea pig estrous cycle. However, neither prolactin secretion nor its regulation by steroid hormones has been characterized, perhaps due to the lack of a specific radioimmunoassay. beta-Endorphin (BE), substance P (SP), and serotonin (5-HT) increase prolactin secretion in rats and monkeys. BE and SP neurons in guinea pigs and 5-HT neurons in monkeys contain progestin receptors which could mediate neuroendocrine effects of steroid hormones. Therefore, the effects of E and P on prolactin, BE, SP, and 5-HT and its metabolite 5-HIAA were examined in guinea pigs which were ovariectomized, E treated (28 days), and E+P treated (14 days E+14 days E+P). The rat NB2 lymphoma cell line was used as a bioassay for serum prolactin. BE and SP levels were measured by radioimmunoassay in four hypothalamic areas: the preoptic region (POA), the mediobasal hypothalamus (MBH), the dorsomedial hypothalamus (DMH), and the mamillary bodies (MB). 5-HT and 5-HIAA were measured in the midbrain raphe area by high-pressur...Continue Reading

Citations

Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
Sep 3, 2010·Brain Research·Martin J Kelly, Jian Qiu
Sep 30, 2000·Brain Research. Brain Research Reviews·L Uphouse
Jun 11, 2010·Endocrinology·S M Khorshed AlamMichael J Soares
Aug 9, 2012·Frontiers in Neuroendocrinology·Martin J Kelly, Oline K Rønnekleiv
Jun 25, 2009·Molecular and Cellular Endocrinology·Martin J Kelly, Oline K Rønnekleiv
Nov 1, 2015·Journal of Affective Disorders·F GressierA Serretti
Jun 10, 2008·Molecular and Cellular Endocrinology·Martin J Kelly, Oline K Rønnekleiv
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Jun 28, 2007·Endocrinology·Troy A RoepkeOline K Rønnekleiv
Jun 24, 2019·Steroids·Todd L StincicMartin J Kelly
Jun 17, 1998·The Journal of Prosthetic Dentistry·T T DaoV Ton-That

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