PMID: 8591108Feb 1, 1995Paper

Effects of progesterone on the metabolism of cancellous bone in young oophorectomized rats

The Journal of Obstetrics and Gynaecology
T FujimakiK Tanaka

Abstract

The effects of progesterone on cancellous bone in young rats were evaluated. Fifty female rats aged 90 days were divided into 5 groups: (1) Sham-operated controls (SHAM); (2) oophorectomized (OVX) rats; (3) OVX rats treated with estrogen (OVX+E); 4) OVX rats treated with progesterone (OVX+P); and (5) OVX rats treated with estrogen and progesterone (OVX+EP). After surgery, some animals were treated subcutaneously (s.c.) with 0.5 mg of estradiol dipropionate depot, with 5 mg of hydroxyprogesterone capronate depot, or with both hormones, at intervals of 7 days. After 180 days, the bone mineral density (BMD) and bone histomorphometry of their lumbar vertebrae and serological parameters were measured. In the OVX+P group, the BMD and the bone volume as shown by bone histomorphometry were slightly higher than in the OVX group, but not significantly. These parameters in the OVX+E and OVX+EP groups were significantly higher than in the OVX group. The OVX+P group showed a significant increase in the labeled surface and a decrease of the osteoclast number, compared to the OVX group. The OVX+P group showed increases of serum alkarine phosphatase and osteocalcin. From these results, it can be concluded that progesterone treatment might inte...Continue Reading

References

May 1, 1990·Endocrine Reviews·J C Prior
Nov 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E I BarengoltsS C Kukreja
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jun 1, 1986·Endocrinology·C GreenbergG A Williams
May 1, 1984·The Journal of Clinical Investigation·Z Bar-ShavitS L Teitelbaum

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Citations

Oct 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E I BarengoltsT G Unterman
Feb 7, 2008·Amino Acids·Qing-Ping WangEr-Yuan Liao
Dec 20, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jean Calleja-Agius, Mark P Brincat
Feb 16, 2008·Endocrinology·David J RickardRussell T Turner
Apr 5, 2020·Orthodontics & Craniofacial Research·Marjorie Ayumi OmoriErika C Küchler
Oct 6, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J Calleja-Agius, M Brincat

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