Effects of progesterone treatment on smoked cocaine response in women

Pharmacology, Biochemistry, and Behavior
Mehmet SofuogluD K Hatsukami

Abstract

The effects of female sex hormones on responses to cocaine have not been systematically investigated in women. In this study, the safety and efficacy of acute progesterone treatment on smoked cocaine response was examined in female cocaine users. Five women had two experimental sessions during the early follicular phase, within 3-9 days after the beginning of their menses. In each experimental session, subjects received a single 200-mg dose of progesterone or placebo orally. Starting 2 h after the medication treatment, subjects received three deliveries of 0.4-mg/kg smoked cocaine 30 min apart. Progesterone treatment, compared to placebo, did not affect the blood pressure and heart rate changes in response to cocaine deliveries. For subjective responses to cocaine, the average of five-item Cocaine Effects Questionnaire (CEQ) was attenuated under progesterone treatment compared to placebo. For individual items of CEQ, progesterone treatment was associated with diminished rating of "feel the effect of last dose" in response to cocaine. These preliminary results suggest that acute progesterone treatment, given during the early follicular phase, may attenuate some of the subjective effects of cocaine. Further studies are warranted ...Continue Reading

References

Mar 11, 1992·Toxicology and Applied Pharmacology·A SharmaJ R Woods
Nov 1, 1990·American Journal of Obstetrics and Gynecology·M A Plessinger, J R Woods
May 1, 1990·Pharmacology, Biochemistry, and Behavior·D HatsukamiM Huber
Aug 1, 1982·Journal of Personality Assessment·M LorrS U Fisher
Jun 1, 1982·Pharmacology, Biochemistry, and Behavior·A Michanek, B J Meyerson
May 1, 1994·Neurotoxicology and Teratology·J C Glantz, J R Woods
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·D K HatsukamiK Hanson
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
May 1, 1996·British Journal of Clinical Pharmacology·K S TanB J Lipworth
Mar 25, 1999·Clinical Therapeutics·B de Lignières
Jul 19, 2000·Pharmacology, Biochemistry, and Behavior·A J Justice, H De Wit
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·M SofuogluD K Hatsukami

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Citations

Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Elena M KouriScott E Lukas
Dec 4, 2003·Psychoneuroendocrinology·Anna H V Söderpalmde Harriet Wit
Mar 10, 2005·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Paula B RepettoMarc A Zimmerman
Mar 1, 2006·Experimental and Clinical Psychopharmacology·Wendy J Lynch
Jul 29, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa R JacksonJill B Becker
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Suzette M Evans, Richard W Foltin
Jan 26, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
May 18, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nancy K MelloJack H Mendelson
Jul 3, 2013·BioMed Research International·Tarek El-Bialy, Adel Alhadlaq
Jan 18, 2005·CNS Drugs·Mehmet Sofuoglu, Thomas R Kosten
Mar 7, 2014·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
Sep 17, 2014·Current Psychiatry Reports·Megan M Moran-Santa MariaKathleen Brady
Feb 24, 2016·Frontiers in Psychiatry·Marilyn E Carroll, John R Smethells
Aug 3, 2010·Psychoneuroendocrinology·Mehmet SofuogluMarc Mooney
Apr 20, 2010·Hormones and Behavior·Stephanie C ReedSuzette M Evans
Oct 20, 2009·Hormones and Behavior·Nancy K Mello
Nov 11, 2009·Hormones and Behavior·Cynthia KuhnQ David Walker
May 19, 2009·Hormones and Behavior·Jill B Becker
Apr 22, 2009·Pharmacology, Biochemistry, and Behavior·Peter T MorganRajita Sinha
Nov 4, 2008·Psychoneuroendocrinology·Matthew W FeltensteinRonald E See
Feb 8, 2008·Pharmacology, Biochemistry, and Behavior·Vanya Quinones-JenabCheryl Frye
Oct 2, 2007·Frontiers in Neuroendocrinology·Jill B Becker, Ming Hu
Jun 15, 2007·Pharmacology, Biochemistry, and Behavior·Andrea R VansickelCraig R Rush
Oct 9, 2012·British Journal of Clinical Pharmacology·Ariadna Forray, Mehmet Sofuoglu
Jun 28, 2012·Social and Personality Psychology Compass·Michiko Sakaki, Mara Mather
Nov 24, 2004·Hormones and Behavior·Eugene D Festa, Vanya Quinones-Jenab
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Mehmet SofuogluThomas R Kosten
Nov 18, 2006·Brain Research·Hui-Bing K WuVanya Quiñones-Jenab
Sep 19, 2006·Pharmacology, Biochemistry, and Behavior·Cheryl A Frye
Feb 7, 2016·Journal of Neuroendocrinology·P StrajharM E Liechti
Dec 11, 2007·Brain Research·Scott J RussoVanya Quiñones-Jenab

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