Effects of prolactin-releasing peptide on tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in estrogen-treated female rats

Journal of Biomedical Science
Zung Fan YuanJenn-Tser Pan

Abstract

Both systemic and central effects of a newly discovered prolactin (PRL)-releasing factor (PRF), prolactin-releasing peptide (PrRP), were determined in this study. Systemic injection of PrRP (1 and 10 microg/rat, i.v.) stimulated PRL secretion in ovariectomized, estrogen-treated rats similar to the effect of another PRF, thyrotropin-releasing hormone (TRH). Pretreatment with a dopamine D2 receptor antagonist, sulpiride (1 microg/rat, i.v.), potentiated the stimulatory effect of both PrRP and TRH on PRL secretion. Using the double-labeling immunohistochemical method, PrRP-immunoreactive terminals were found in close contact with tyrosine-hydroxylase-immunoreactive neurons in the hypothalamic arcuate nucleus. Central administration of PrRP (0.1-1,000 ng/rat, i.c.v.) stimulated tuberoinfundibular but not nigrostriatal dopaminergic neuronal activity in 15 min. Levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in the median eminence and striatum were used as indices for tuberoinfundibular dopaminergic (TIDA) and nigrostriatal dopaminergic neuronal activities, respectively. The serum PRL level, however, was not significantly changed. Similar treatment with TRH (10 ng/rat, i.c.v.) stimulated and inhibited TIDA neuronal activity and seru...Continue Reading

References

Oct 1, 1978·European Journal of Pharmacology·M RubergA Enjalbert
Jun 1, 1988·Endocrinology·J F Hyde, N Ben-Jonathan
May 7, 1971·Biochemical and Biophysical Research Communications·A H TashjianD K Jensen
Jun 2, 1998·Nature·S HinumaM Fujino
Jun 11, 1999·Biochemical and Biophysical Research Communications·H MatsumotoM Fujino
Sep 25, 1999·Regulatory Peptides·R FujiiM Fujino
Mar 10, 2000·Brain Research Bulletin·Y LeeJ L Voogt
Apr 25, 2000·Neuroendocrinology·H JarryK Bauer
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy

❮ Previous
Next ❯

Citations

Jul 7, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Sayuki KitagawaKen-ichi Yayou
Apr 8, 2020·Experimental and Therapeutic Medicine·Chengcheng ZhengZuyue Sun
Nov 27, 2014·Frontiers in Endocrinology·Tetsuya Tachibana, Tatsuya Sakamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved