Effects of prolonged exposure to CO2 on behaviour, hormone secretion and respiratory muscles in young female rats

Physiology & Behavior
J M MartretteM Trabalon

Abstract

Atmospheric CO2concentrations increased significantly over the last century and continuing increases are expected to have significant effects on current ecosystems. This study evaluated the behavioural and physiological (hormone status, muscle structure) effects of prolonged CO2exposure in young female Wistar rats exposed at 700ppm of CO2during 6h a day for 15days. Prolonged CO2exposure, though not continuous, produced significant disturbances in behaviour with an increase in drinking, grooming and resting, and a reduction in rearing, jumping-play and locomotor activity. Furthermore, CO2exposure was accompanied by increased plasma levels of corticosterone, suggesting that prolonged exposure to CO2was stressful. The muscular structure can also be modified also when respiratory working conditions change. The expression of myosin heavy chain was significantly affected in the diaphragm and oral respiratory muscles: Masseter Superficialis and Anterior Digastric. Modified behaviour and hormonal changes both appear to be at the origin of the observed muscular adaptation.

Citations

Apr 11, 2021·Respiratory Research·David SchnebergerShelley Kirychuk

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