Effects of prolonged mechanical ventilation and inactivity on piglet diaphragm function

Intensive Care Medicine
P RadellL I Eriksson

Abstract

Muscle weakness is associated with immobilization, prolonged mechanical ventilation, critical illness and various critical care therapies. This study used an animal model simulating the critical care environment to investigate the effects of 5 days' mechanical ventilation and inactivity on diaphragm contractility and neurophysiologic function. Prospective laboratory study. Animal research laboratory. Seven 2-3 month old piglets weighing 20-25 kg. The animals received constant-flow, volume-controlled mechanical ventilation (Tv 12-15 ml/kg, PEEP 3-5 cmH2O, I:E 1:2) and sedation without paralysis, and spontaneous breathing efforts were prevented. Evoked diaphragm contractions were achieved by transvenous phrenic nerve pacing. Transdiaphragmatic pressure (Pdi) measurements were used to assess force frequency relationships. Evoked electrophysiologic measures included lowest stimulus threshold and latency, compound muscle action potential (CMAP) amplitude and duration, and amplitude during repetitive nerve stimulation at 3 Hz. Lung function measures included airway pressures, tidal and minute volumes, and dynamic compliance and resistance. There were no clinically significant changes in hemodynamics, oxygenation or ventilation. Indir...Continue Reading

Citations

Oct 12, 2007·Intensive Care Medicine·Theodoros Vassilakopoulos
Feb 6, 2010·Critical Care Medicine·Scott K PowersSanford Levine
Mar 6, 2010·Journal of Applied Physiology·Melissa A WhiddenScott K Powers
Apr 19, 2003·American Journal of Respiratory and Critical Care Medicine·Gábor Z RáczMarc Decramer
Jan 24, 2004·American Journal of Respiratory and Critical Care Medicine·Theodoros Vassilakopoulos, Basil J Petrof
Aug 7, 2004·American Journal of Respiratory and Critical Care Medicine·R Andrew ShanelyScott K Powers
Jun 18, 2004·American Journal of Respiratory and Critical Care Medicine·Catherine S H SassoonVincent J Caiozzo
Sep 18, 2004·American Journal of Respiratory and Critical Care Medicine·Jenna L BettersScott K Powers
Oct 14, 2008·American Journal of Respiratory and Critical Care Medicine·Karen MaesGhislaine Gayan-Ramirez
Sep 4, 2010·American Journal of Respiratory and Critical Care Medicine·Samir JaberStefan Matecki
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Liying YangBasil J Petrof
Jun 27, 2003·American Journal of Respiratory and Critical Care Medicine·Franco Laghi, Martin J Tobin
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Catherine S H Sassoon
Nov 26, 2004·American Journal of Respiratory and Critical Care Medicine·Marc Decramer, Ghislaine Gayan-Ramirez
Apr 5, 2011·Critical Care : the Official Journal of the Critical Care Forum·Samir JaberBasil J Petrof
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Theodoros VassilakopoulosCharis Roussos
Sep 23, 2009·Critical Care : the Official Journal of the Critical Care Forum·Catherine Sh Sassoon, Vincent J Caiozzo
Jul 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Greet HermansGhislaine Gayan-Ramirez
Jul 26, 2005·Intensive Care Medicine·Samir JaberStefan Matecki
May 23, 2012·Archivos de bronconeumología·Antonio A M CastroElías Ferreira Porto
Apr 13, 2012·Archivos de bronconeumología·Antonio A M CastroElias Ferreira Porto
Oct 3, 2006·Critical Care Medicine·Dries TestelmansGhislaine Gayan-Ramirez
Jul 20, 2012·Critical Care Medicine·Anouk AgtenGhislaine Gayan-Ramirez
Dec 8, 2015·Critical Care : the Official Journal of the Critical Care Forum·Tom SchepensPhilippe G Jorens
Aug 1, 2015·The Journal of Physiology·Lars LarssonBarry Dworkin
Aug 13, 2005·Acta Anaesthesiologica Scandinavica·K FredrikssonO Rooyackers
Mar 18, 2004·Acta Anaesthesiologica Scandinavica·P RadellT Ansved
Aug 31, 2006·Acta Anaesthesiologica Scandinavica·H NormanL Larsson
Apr 19, 2003·Intensive Care Medicine·Ghislaine Gayan-RamirezMarc Decramer
Apr 10, 2015·Journal of Cellular and Molecular Medicine·Cléber VeronaMara S Benfato
Mar 12, 2015·American Journal of Respiratory and Critical Care Medicine·Pleuni E HooijmanCoen A C Ottenheijm
Apr 1, 2016·Journal of Cachexia, Sarcopenia and Muscle·David BergerJoerg C Schefold
Dec 9, 2016·Journal of Clinical Medicine·Bruno-Pierre Dubé, Martin Dres
Mar 2, 2012·Acta Cirúrgica Brasileira·André de Sá Braga OliveiraPaloma Lys de Medeiros
Nov 26, 2009·Current Opinion in Critical Care·Basil J PetrofStefan Matecki
Oct 29, 2011·Physiological Measurement·Caroline ArmbrusterStefan Schumann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Jonne DoorduinLeo M A Heunks
American Journal of Respiratory and Critical Care Medicine
Sanford LevineMurat T Budak
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Huibin TangJoseph B Shrager
© 2022 Meta ULC. All rights reserved