Effects of prolonged nitrous oxide exposure on hemopoietic stem cells in mice

Journal of Anesthesia
M KonnoR Wakusawa

Abstract

The effects of prolonged exposure to nitrous oxide on the hemopoietic progenitor cells in bone marrow and spleen in mice were investigated. Fifty percent nitrous oxide caused a marked decrease in the number of pluripotent stem cells (CFU-S) and granulocyte-macro-phage progenitor cells (GM-CFC) in the spleen, whereas it caused only a slight decrease in these cells in the bone marrow. These results suggest that prolonged exposure to nitrous oxide induces damage in the splenic hemopoiesis in mice.

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Citations

Apr 18, 2006·Journal of Critical Care·Dan TorbatiBalagangadhar R Totapally

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