Effects of prolonged wakefulness on c-fos and AP1 activity in young and old rats

Brain Research. Molecular Brain Research
R Basheer, P J Shiromani

Abstract

Recent studies have demonstrated that the immediate-early gene c-fos is induced in neuronal populations responsible for specific sleep-wake states. The induction of this gene may be functionally relevant to sleep homeostasis since without the gene mice (c-fos null) take longer to fall asleep and have a selective reduction in slow-wave sleep. This suggests that a build-up of c-fos during wakefulness increases the drive to sleep and lack of c-fos is associated with reduced sleep. Sleep also has an effect on c-Fos serving to eliminate the protein rapidly. Waxing and waning of transcription factors such as c-Fos may influence slow, oscillating events such as sleep and wakefulness. To further examine what role c-Fos may play in regulating sleep, the present study examined the effects of prolonged wakefulness on c-Fos and AP-1 activity in young (3.5 months old) and old (21.5 months old) Sprague--Dawley rats. Previously we found that old rats slept less even after prolonged wakefulness, and other investigators have found that aging is also associated with a decline in c-Fos. In the present study, we reasoned that prolonged wakefulness would also fail to increase c-Fos in old versus young rats. The baseline levels of c-Fos and AP-1 act...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·K RiabowolM Z Gilman
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·S R Ticho, M Radulovacki
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·H MatsumuraO Hayaishi
Sep 1, 1993·Neurobiology of Aging·E L SutinT S Kilduff
Aug 1, 1993·The European Journal of Neuroscience·G Grassi-ZucconiM Bentivoglio
Mar 1, 1993·Brain Research. Molecular Brain Research·C A LandisN R Smalheiser
Jan 12, 1996·Science·J E SherinC B Saper
Jan 1, 1996·Neurobiology of Aging·I RetchkimanA P Wagner
Jan 1, 1997·Neurobiology of Aging·A H Nagahara, R J Handa
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
Jun 1, 1995·Journal of Sleep Research·C CirelliG Tononi
Oct 20, 2000·Brain Research. Molecular Brain Research·P J ShiromaniM E Charness

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Citations

Jul 1, 2002·Journal of the American Aging Association·Hyon Jeen KimHae Young Chung
Apr 16, 2004·Behavioural Brain Research·Peter SalchnerNicolas Singewald
Dec 31, 2003·Neuroscience·E Murillo-RodriguezP J Shiromani
Oct 24, 2002·Neurobiology of Aging·Rafael J Salin-PascualPriyattam J Shiromani
Aug 6, 2002·Respiratory Physiology & Neurobiology·Immanuela Ravé Moss
Jun 29, 2010·Archivos de bronconeumología·Miguel Angel Martínez-GarcíaJosé María Montserrat
Apr 9, 2010·Alcoholism, Clinical and Experimental Research·Mahesh M ThakkarPradeep Sahota
Dec 30, 2015·PloS One·João Sollari LopesRui F Oliveira
Mar 20, 2018·Molecular and Cellular Biochemistry·Shaffi ManchandaGurcharan Kaur
Oct 27, 2004·Journal of Psychiatric Research·Andrea DzajaTarja Porkka-Heiskanen

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