Effects of prone position on the oxygenation of patients with acute respiratory distress syndrome

São Paulo Medical Journal = Revista Paulista De Medicina
Heloisa Baccaro RossettiJosé Luiz Gomes do Amaral

Abstract

Acute respiratory distress syndrome (ARDS) is characterized by arterial hypoxemia, and prone position (PP) is one possible management strategy. The objective here was to evaluate the effects of PP on oxygenation. Non-randomized, open, prospective, controlled clinical trial, in a surgical intensive care unit at a tertiary university hospital. Forty-one ARDS patients underwent PP for three-hour periods. Arterial partial oxygen pressure (PaO2) was measured immediately before changing to PP, after 30, 60, 120 and 180 minutes in PP and 60 minutes after returning to dorsal recumbent position (DP). The paired-t and Dunnett tests were used. A notable clinical improvement in oxygenation (> 15%) was detected in 78.0% of patients. This persisted for 60 minutes after returning to DP in 56% and lasted for 12 and 48 hours in 53.6% and 46.3%, respectively. Maximum improvement was seen after 30 minutes in 12.5% of responding patients and after 180 minutes in 40.6%. No statistically significant associations between PP response and age, gender, weight, PEEP level, tidal volume, respiratory rate, PaO2/FiO2 or duration of mechanical ventilation were detected. One accidental extubation and four cases of deterioration through oxygenation were detect...Continue Reading

References

Jun 1, 1992·Journal of Applied Physiology·K C BeckK Rehder
Sep 1, 1974·Anesthesiology·A B Froese, A C Bryan
Mar 1, 1970·Journal of Applied Physiology·J H Reed, E H Wood
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·D DreyfussG Saumon
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·L GattinoniF Valenza
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·W J LammR K Albert
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·G ChatteD Robert
Nov 5, 1997·Intensive Care Medicine·S E Sinclair, R K Albert
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·P PelosiL Gattinoni
Feb 26, 1998·American Journal of Respiratory and Critical Care Medicine·L PapazianJ P Auffray
May 23, 1998·Acta Anaesthesiologica Scandinavica·H FlaattenO Hevrøy
Sep 1, 2001·The New England Journal of Medicine·L GattinoniUNKNOWN Prone-Supine Study Group
Nov 5, 2002·The European Respiratory Journal·P PelosiL Gattinoni
Dec 17, 2002·Respiratory Care Clinics of North America·Gemma Rialp, Jordi Mancebo
Jan 1, 1961·Journal of Applied Physiology·F MORENO, H A LYONS
Dec 4, 2003·Intensive Care Medicine·Jason EasbyStephen Graham

❮ Previous
Next ❯

Citations

Jan 5, 2011·Nursing in Critical Care·Angie D Wright, Maria Flynn
Jul 30, 2009·AACN Advanced Critical Care·Karen L Johnson, Tim Meyenburg
Mar 1, 2012·International Journal of Epidemiology·Prasanna SamuelCaroline H D Fall
Nov 7, 2015·Current Opinion in Anaesthesiology·Ushma ShahFrances Chung
Dec 18, 2013·The International Journal of Artificial Organs·Valesca KippingMaria Deja

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.