Effects of propionyl-carnitine on mitochondrial respiration and post-ischaemic cardiac function in the ischaemic underperfused diabetic rat heart

Drugs in R&D
Tom L BroderickMelissa Gillis

Abstract

Carnitine and its derivatives, namely propionyl-carnitine (PC), have been shown to protect cardiac metabolism and function in diabetes mellitus and ischaemic heart disease. Since diabetes is associated with abnormalities in mitochondrial metabolism of fuels, we examined the effects of PC on mitochondrial respiration in ischaemic hearts from streptozotocin-diabetic rats. Diabetes was induced in Sprague-Dawley rats by an intravenous injection of streptozotocin. Following the diagnosis of diabetes, oral PC treatment was initiated for a period of 6 weeks. After treatment, cardiac function was determined from working hearts perfused under aerobic conditions and in a separate group of hearts subjected to ischaemia and reperfusion. Mitochondrial respiration was determined under aerobic conditions and following low-flow ischaemia. Rates of state 3 mitochondria respiration with pyruvate were significantly lower in diabetic (n = 4) hearts compared with control (n = 6) hearts (80 +/- 5 vs 112 +/- 5 nanoatoms O2/mg protein/min, respectively), but those with palmitoylcarnitine were similar (101 +/- 11 vs 106 +/- 6 nanoatoms O2/mg protein/min). Diabetic rat heart (n = 8) function, expressed as rate pressure product, was also significantly de...Continue Reading

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Citations

Nov 21, 2014·PLoS Neglected Tropical Diseases·Núria GironèsManuel Fresno
Jan 21, 2006·Cardiovascular Diabetology·John I MaloneDouglas D Schocken

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