Abstract
Patients with severe brain injury often require long-term sedation and have a high incidence of nosocomial infections, causing an increased mortality rate. However, whether anesthetic drugs might contribute to immunosuppressive effects remains unclear. In this prospective study, we investigated the effects of propofol (4-6 mg x kg(-1) x h(-1)) and methohexital (1-3 mg x kg(-1) x h(-1)) on neutrophil leukocyte function and immune status in 21 patients with brain injury who either received propofol (n = 12; 9 male, 3 female; mean age, 51 +/- 15 years) or methohexital (n = 9; 8 male, 1 female; mean age, 48 +/- 17 years) after admission to the intensive care unit (ICU). Both sedatives were administered over 7 days and individual dosage was adapted according to clinical requirements. Neutrophil leukocyte function was assessed as phagocytosis and respiratory oxidative burst activity. Furthermore, leukocyte subpopulations, and surface markers of lymphocytes and monocytes (CD3; CD4; CD45RO; CD4/CD45RO; CD25; CD4 and CD25; CD54; CD69; CD14/HLA-DR; CD8; CD3/HLA-DR; CD4 : CD8 ratio) were assessed. Blood samples were drawn on ICU admission, and on days 3, 7, and 14. Patients' demographics were compared by Wilcoxon test and laboratory resul...Continue Reading
References
Jan 1, 1992·Infection·K E EberhardtW R Maskos
Apr 8, 1991·Journal of Immunological Methods·G RotheG Valet
Mar 1, 1995·British Journal of Anaesthesia·J A DavidsonG Ramsay
Aug 1, 1994·Glycoconjugate Journal·M DukE Lisowska
Nov 1, 1994·Acta Anaesthesiologica Scandinavica·A SkoutelisH Bassaris
Jun 1, 1993·Journal of Clinical Pharmacy and Therapeutics·D Bertram, R Summers
Dec 1, 1995·Anaesthesia·C O PirttikangasO Peltola
Apr 1, 1996·Anaesthesia·C O PirttikangasO Peltola
May 1, 1996·Immunopharmacology and Immunotoxicology·M WeissE M Schneider
Sep 1, 1996·European Journal of Anaesthesiology·P G MurphyS M Whiteley
Sep 1, 1996·British Journal of Anaesthesia·J HeineS Piepenbrock
Nov 1, 1996·European Journal of Anaesthesiology·D FröhlichK Taeger
Jan 1, 1997·Critical Care Medicine·M WeissE M Schneider
Sep 5, 1998·Anesthesia and Analgesia·K MikawaY Niwa
Nov 20, 1998·Anesthesiology·B LarsenM Bauer
Dec 5, 2000·British Journal of Anaesthesia·J HeineM Leuwer
Feb 13, 2001·Anesthesia and Analgesia·T InadaS Nakao
Apr 12, 2001·European Journal of Anaesthesiology·W KrumholzG Hempelmann
Jun 20, 2001·European Journal of Anaesthesiology·J MühlingG Hempelmann
May 1, 2002·Anesthesiology·Torsten LoopBenedikt H J Pannen
Jul 13, 2002·European Journal of Anaesthesiology·D FröhlichK Taeger
Jun 14, 2003·Acta Anaesthesiologica Scandinavica·J ZhaoS Piepenbrock
Citations
Apr 22, 2011·Der Anaesthesist·P HilbertR Stuttmann
Aug 8, 2008·Journal of Anesthesia·Shin Kurosawa, Masato Kato
May 29, 2009·British Journal of Anaesthesia·N R Webster, H F Galley
Nov 15, 2011·Anesthesiology Clinics·Robert D SandersMervyn Maze
Nov 15, 2011·Anesthesiology Clinics·John W Devlin, Russel J Roberts
Jul 6, 2010·Biochimica Et Biophysica Acta·Jing TangMiaoning Gu
Jul 7, 2009·Critical Care Clinics·John W Devlin, Russel J Roberts
Jul 7, 2009·Critical Care Clinics·Robert D SandersMervyn Maze
Aug 23, 2017·World Journal of Critical Care Medicine·Luciana Boavista Barros HeilPatricia Rieken Macedo Rocco
Aug 5, 2018·Journal of Cellular Biochemistry·Yunes PanahiAmirhossein Sahebkar