PMID: 9551748Apr 29, 1998Paper

Effects of proportional assist ventilation on exercise tolerance in COPD patients with chronic hypercapnia

The European Respiratory Journal
L BianchiN Ambrosino

Abstract

This study investigates the impact of proportional assist ventilation (PAV), a new mode of partial ventilatory support, on exercise tolerance and breathlessness in severe hypercapnic chronic obstructive pulmonary disease (COPD) patients. We also examined the effects of continuous positive airway pressure (CPAP) and pressure support ventilation (PSV). On two consecutive days, 15 stable hypercapnic COPD patients underwent four endurance tests on a cycle ergometer at 80% of their maximal workrate, receiving, via a nasal mask in random order, either: 1) sham ventilation (CPAP: 1 cmH2O); 2) CPAP (6 cmH2O); 3) PSV (inspiratory pressure support: 12-16 cmH2O; expiratory positive airway pressure (EPAP): 1 cmH2O); or 4) PAV (8.6+/-3.6 cmH2O x L(-1) and 3+/-1.3 cmH2O x L(-1)x s(-1) of volume and flow assistance, respectively plus EPAP: 1 cmH2O). Oxygen supply was standardized to maintain an arterial oxygen saturation (Sa,O2) of 92-93%. Breathing pattern and minute ventilation (by respiratory inductive plethysmography), pulse oximetry, end tidal partial pressure of CO2, cardiac frequency and sensations of dyspnoea and leg discomfort (by Borg scale) were monitored. In comparison to sham ventilation, PAV, PSV and CPAP were able to increase t...Continue Reading

Associated Clinical Trials

Citations

Jun 21, 2001·Journal of Cardiopulmonary Rehabilitation·P HernandezS B Gottfried
Apr 11, 2008·The Journal of Trauma·Jay A JohannigmanRichard D Branson
Feb 13, 2009·Respirology : Official Journal of the Asian Pacific Society of Respirology·Collette MenadueElizabeth R Ellis
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Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·S Mehta, N S Hill
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Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Ioannis VogiatzisSpyros Zakynthinos
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Luis Puente-Maestu, William W Stringer
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Nov 2, 2015·Revue des maladies respiratoires·F-É GravierC Tardif
Feb 19, 2008·Respiratory Medicine·Jean-Christian BorelJean-Louis Pépin
Mar 27, 2007·Respiratory Medicine·Nicolino Ambrosino, Anita Simonds
Feb 22, 2012·Respiratory Medicine·A M MogaJ Spahija
Apr 16, 2015·Multidisciplinary Respiratory Medicine·Nicolino Ambrosino, Paolo Cigni
Sep 21, 2010·Respiratory Medicine·Omar HussainFranco Laghi
Apr 22, 2015·Respiratory Medicine·Andrea RossiMarc Miravitlles
Aug 2, 2003·Journal of Cardiopulmonary Rehabilitation·Frédéric CostesJean Claude Barthélémy
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Jan 18, 2019·Journal of Clinical Medicine·Ioannis VogiatzisStephen C Bourke
Aug 7, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Guillaume PrieurGregory Reychler

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