PMID: 6109991Feb 14, 1981Paper

Effects of prosomatostatin on growth hormone and prolactin response to arginine in man. Comparison with somatostatin

Lancet
M D Rodriguez-ArnaoR Hall

Abstract

The effects of the hypothalamic 28 aminoacid peptide prosomatostatin (Pro-SS) on arginine-induced growth hormone (GH) and prolactin (PRL) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin (SS). In comparison with SS, Pro-SS caused greater and more prolonged inhibition of GH release, a more marked reduction of the PRL response to arginine, and greater enhancement of the hyperglycaemic action of arginine. The greater potency and prolonged action of Pro-SS make it an interesting tool to study hormonal control mechanisms in a variety of physiological and pathological conditions.

References

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Citations

Mar 1, 1989·Journal of Affective Disorders·R ThomasM Scanlon
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M G de QuijadaA V Schally
Jan 1, 1994·European Journal of Clinical Investigation·P HildebrandC Beglinger
Aug 1, 1987·Acta Psychiatrica Scandinavica·D R ThomasR John
Aug 1, 1982·Clinical Endocrinology·R P MillarN Ling
Jan 1, 1986·European Journal of Clinical Pharmacology·N S KhurmiE B Raftery
Aug 1, 1984·Journal of Endocrinological Investigation·C RedekoppR A Donald
Jan 1, 1987·General and Comparative Endocrinology·S Harvey, T R Hall
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Gómez-Pan, M D Rodriguez-Arnao
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J A Wass

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