Effects of prostacyclin on cardiovascular reflexes from the ventricular epicardium of the dog: comparison with the effects of prostaglandin E2

Prostaglandins
J Staszewska-BarczakP N Nolan

Abstract

Application of bradykinin to the exposed ventricular surface of the dog's heart produced reflex pressor effects and tachycardia, whereas application of nicotine evoked reflex hypotension and bradycardia. Prostacyclin (PGI2) or prostaglandin E2 (PGE2), when applied epicardially, had no effects by themselves but potentiated the reflex pressor changes to bradykinin; the depressor responses to nicotine were not changed. The potentiating effect of PGI2 was prompt but short-lived, whereas that of PGE2 was slow in onset but prolonged. The results suggest that PGI2, which is present in the pericardial fluid, may contribute to signalling of pain and reflex circulatory changes when kinin formation occurs during myocardial ischaemia or pericardial inflammation.

References

Sep 1, 1977·Clinical and Experimental Pharmacology & Physiology·J Staszewska-Barczak, G J Dusting
Jul 1, 1978·Prostaglandins·S H FerreiraM S de Abreu Castro
Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T H HintzeG Kaley
Jun 12, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·F R NetoA Antonio
Jan 1, 1974·Japanese Heart Journal·Y Uchida, S Murao

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Citations

Jul 20, 1983·The American Journal of Cardiology·G J DustingT J Martin
Dec 1, 1982·Prostaglandins·R D NolanT J Martin
Jan 1, 1990·Pharmacology & Therapeutics·G J Dusting, P S MacDonald
Jul 8, 1998·European Journal of Pharmacology·M Kuwahara, M Kuwahara
Jan 1, 1985·Clinical and Experimental Pharmacology & Physiology·P N NolanJ Staszewska-Woolley

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