Effects of prostacyclin (PGI2) on vulnerability to ventricular fibrillation in the normal and ischemic canine heart

European Journal of Pharmacology
P R KoweyB Lown


Prostacyclin (PGI2) has been shown to have a number of beneficial effects on the cardiovascular system. However, its effects on ventricular electrical properties remain unexplored. We studied the effects of this naturally occurring humoral agent on ventricular vulnerability in the normal heart and in two models of myocardial ischemia: coronary artery occlusion and release and ergonovine-induced coronary vasoconstriction. Prostacyclin lowered the vulnerable period threshold in the normal animal. PGI2 had no effect on ventricular vulnerability when the blood pressure was controlled with phenylephrine and was not protective during either occlusion or release. However, when blood pressure was controlled, PGI2 did not reverse the vasoconstrictor and profibrillatory effects of ergonovine.


Oct 1, 1977·European Journal of Pharmacology·G J DustingJ R Vane
Feb 1, 1978·Circulation Research·T M FitzpatrickP A Kot
May 18, 1978·The New England Journal of Medicine·P Needleman, G Kaley
Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A L HymanJ Barton
Dec 1, 1978·Cardiovascular Research·G J DustingJ R Vane
Oct 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·T H HintzeG Kaley
Sep 1, 1979·Prostaglandins and Medicine·R K DixT Lawrence
Mar 1, 1977·Circulation Research·T H Hintze, G Kaley
Aug 1, 1977·Journal of Molecular and Cellular Cardiology·D J Hearse
Sep 1, 1971·The American Journal of Cardiology·B Surawicz
Dec 1, 1973·European Journal of Pharmacology·G J Kelliher, T M Glenn
Apr 1, 1980·The American Journal of Cardiology·F A Heupler
Aug 1, 1981·The American Journal of Cardiology·J Mehta, P Mehta

Related Concepts

Diastolic Blood Pressure
Coronary Circulation
Coronary Heart Disease
Sinus Node Artery
Canis familiaris
Pulse Rate

Related Feeds


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.