PMID: 1206276Nov 1, 1975Paper

Effects of prostaglandin F2alpha and E2 on the production of progesterone by human granulosa cells in tissue culture

The Journal of Endocrinology
K P McNattyR S Sawers

Abstract

Human granulosa cells with differing steroidogenic potentials were cultured in vitro. The effects of prostaglandin F2alpha (PGF2alpha) and PGE2 on the progesterone output and viability of these cells were investigated. Prostaglandin F2alpha either alone or in combination with LH and FSH inhibited the production of progesterone over a wide range of concentrations (1-8000 ng/ml). However, the inhibitory effect of PGF2alpha was 200 times less effective when the cells were exposed to LH and FSH for 6 days before the addition of the prostaglandin. By contrast PGE2, at concentrations from 1 to 500 ng/ml, markedly stimulated the production of progesterone by granulosa cells, and this was not prevented by the addition of PGF2alpha. The degree of inhibition by PGF2alpha or stimulation by PGE2 was related to the biosynthetic capacity of the cells. These studies suggest that PGF2alpha may act directly on the adenylate cyclase system of human granulosa cells by blocking its activation by LH, and they demonstrate that functional regression of the luteal cell can be induced independently of the blood vascular system.

Citations

Aug 2, 2001·Biochemical and Biophysical Research Communications·T E HarrisD R Abayasekara
Sep 1, 1977·Contraception·R J Aitken, M J Harper
Dec 1, 1978·Prostaglandins·J QuagliarelloG Weiss
Oct 1, 1982·Prostaglandins·R B ReddochD T Armstrong
Dec 1, 1983·Molecular and Cellular Endocrinology·L J DorflingerH R Behrman
Dec 1, 1991·Molecular and Cellular Endocrinology·A E Michael, G E Webley
Nov 1, 1993·Molecular and Cellular Endocrinology·D R AbayasekaraA P Flint
Oct 2, 2001·Prostaglandins & Other Lipid Mediators·G Basini, C Tamanini
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J P ThomasH R Behrman
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Dec 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·T J Gelety, G Chaudhuri
Nov 1, 1978·Clinics in Endocrinology and Metabolism·K P McNatty
Oct 1, 1982·General and Comparative Endocrinology·Y S Chang, F L Huang
Jul 1, 1980·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J P BalmacedaR H Asch
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Yuyi ZhongJiaqi Li
Jan 1, 1987·Reproductive Toxicology·M C Rao, G Gibori

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