Effects of prostaglandin-mediated and cholinergic-mediated miosis on morphology of the ciliary cleft region in dogs

American Journal of Veterinary Research
Sangwan ParkKangmoon Seo

Abstract

OBJECTIVE To compare morphology of the ciliary cleft (CC) region in dogs after topical administration of latanoprost, pilocarpine, or a combination of latanoprost and pilocarpine. ANIMALS 6 Beagles. PROCEDURES A prospective 4-phase crossover study with washout periods was performed. Latanoprost (phase L), pilocarpine (phase P), pilocarpine followed by latanoprost (phase PL), and latanoprost followed by pilocarpine (phase LP) were administered to the right eye. Artificial tears were administered to the left eye (control eye). For each phase, pupil diameter and intraocular pressure (IOP) were measured and ultrasonographic biomicroscopy was performed 2 hours after topical treatment. Angle opening distance (AOD), ciliary cleft width (CCW), ciliary cleft length (CCL), and ciliary cleft area (CCA) were evaluated. RESULTS All treated eyes had marked miosis without significant differences in pupil diameter among phases. Significant IOP reductions were detected for all phases, except phase P. The AOD and CCA were significantly increased in all phases for treated eyes, compared with results for control eyes. The CCW was significantly increased in phases P, PL, and LP; CCL was significantly increased in phases PL and LP. Comparison of tre...Continue Reading

References

May 1, 1978·The British Journal of Ophthalmology·I GriersonS Abraham
Jan 1, 1996·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·T TaniguchiY Kitazawa
Jun 1, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·F J CarrerasF González-Caballero
Jun 1, 2001·American Journal of Ophthalmology·C B TorisM E Yablonski
Sep 3, 2002·Survey of Ophthalmology·Carol B TorisCarl B Camras
Dec 17, 2008·Survey of Ophthalmology·Carol B TorisPaul L Kaufman
May 17, 2014·Investigative Ophthalmology & Visual Science·Darryl R OverbyElke Lütjen-Drecoll
Sep 1, 2015·The Veterinary Clinics of North America. Small Animal Practice·Anthony F AlarioStefano Pizzirani
Oct 13, 2015·The Veterinary Clinics of North America. Small Animal Practice·Paul E Miller, Ellison Bentley

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