PMID: 742941Jan 1, 1978

Effects of prostaglandins and indomethacin on rat epididymal responses to norepinephrine and acetylcholine

Archives of Andrology
J Hib, P Oscar

Abstract

Prostaglandins E2 and F2alpha tromethamine salt caused an increase in amplitude and frequency of rat epididymal contractions. Moreover, they caused a significant potentiation of contractile responses of epididymal smooth muscle to stimulation by norepinephrine or acetylcholine. Indomethacin treatment caused no changes in the spontaneous motility, and this inhibitor of prostaglandins synthesis decreased the responses of epididymis to norepinephrine or acetylcholine. Spontaneous motility of epididymis is possible in the presence of smaller amounts of endogenous prostaglandins, and sudden contraction occurring during ejaculation, induced by sympathetic and parasympathetic nerves stimulation, could be influenced or modulated by prostaglandins.

References

Dec 1, 1975·Fertility and Sterility·M C da Silva e SouzaA L Gimeno
Feb 1, 1975·Journal of Reproduction and Fertility·S K SaksenaM C Chang
Sep 15, 1974·Experientia·M C da Silva e SouzaA L Gimeno
Apr 1, 1958·The Journal of Endocrinology·B A CROSS, T D GLOVER

Citations

Sep 25, 2008·Pakistan Journal of Biological Sciences : PJBS·R MasoumiM Zhandi
Sep 22, 2001·Biology of Reproduction·E MarósticaC S Porto
May 1, 1984·Journal of Andrology·M J CosentinoA T Cockett

Related Concepts

Acetylcholine Sulfate (1: 1)
Epididymis
Osmosin
Inotropism
Norepinephrine, (+, -)-Isomer
Prostaglandins
Prostaglandins E
Prostaglandins F

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