PMID: 1208888Dec 1, 1975Paper

Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia

Prostaglandins
T TylerS Cassin

Abstract

Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20% and 14%, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.

References

Feb 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·S CassinR Wallis
Sep 19, 1973·Nature: New Biology·J OrehekA Bouhuys
Apr 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·P J KadowitzA L Hyman

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Citations

Feb 15, 1979·European Journal of Pharmacology·C W Leffler, J R Hessler
Nov 1, 1977·Prostaglandins·M D MitchellG D Thorburn
Dec 1, 1984·Prostaglandins·C W LefflerR S Green
Sep 1, 1978·Prostaglandins and Medicine·T L TylerS Cassin
Mar 1, 1982·The Journal of Pediatrics·S J SoiferM A Heymann

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